Featured Research

from universities, journals, and other organizations

New Colon Cancer Gene Discovered

Date:
July 9, 2003
Source:
Case Western Reserve University
Summary:
Researchers at Case Western Reserve University and University Hospitals of Cleveland report finding a new gene that is switched off early in the development of colon cancer.

Researchers at Case Western Reserve University and University Hospitals of Cleveland report finding a new gene that is switched off early in the development of colon cancer. The gene, called SLC5A8, is inactivated in 60 percent of human colon cancers, according to their paper in the July 8th issue of the Proceedings of the National Academy of Sciences.

Related Articles


"The normal version of the gene suppresses the growth of colon cancer tumors, both in the test tube and when grown in mice," says senior author of the paper, Sanford Markowitz, M.D., a professor in the Ireland Cancer Center and a Howard Hughes investigator at CWRU and UHC. "However, in our study, we found the silencing of this tumor suppressor gene is a common and early event in human colon cancer."

A biochemical process called aberrant methylation turns off the gene. "We have found that we can detect the abnormal methylated SLC5A8 DNA in the blood of certain patients with colon cancer as a marker of the disease,"says Markowitz. This makes the abnormal gene a possible candidate for a new diagnostic test for the early detection of colon cancer, the second leading cause of cancer death in adult Americans.

The researchers also found that the gene transports a mystery substance into the colon cell, by coupling it to the movement of sodium into the cell. "In further studies, we hope to determine the identity of the mystery substance, which could be a potential target for the development of new anti-colon cancer drugs,"says Markowitz.

The research was supported by Public Health Service grants and by the National Colon Cancer Research Alliance.


Story Source:

The above story is based on materials provided by Case Western Reserve University. Note: Materials may be edited for content and length.


Cite This Page:

Case Western Reserve University. "New Colon Cancer Gene Discovered." ScienceDaily. ScienceDaily, 9 July 2003. <www.sciencedaily.com/releases/2003/07/030709063931.htm>.
Case Western Reserve University. (2003, July 9). New Colon Cancer Gene Discovered. ScienceDaily. Retrieved March 6, 2015 from www.sciencedaily.com/releases/2003/07/030709063931.htm
Case Western Reserve University. "New Colon Cancer Gene Discovered." ScienceDaily. www.sciencedaily.com/releases/2003/07/030709063931.htm (accessed March 6, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, March 6, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Just A Half-Hour Of Lost Sleep Could Lead To Weight Gain

Just A Half-Hour Of Lost Sleep Could Lead To Weight Gain

Newsy (Mar. 6, 2015) A new study found losing just half an hour of sleep could make you gain weight. Video provided by Newsy
Powered by NewsLook.com
Suicide Rates Up For Young Women In U.S.

Suicide Rates Up For Young Women In U.S.

Newsy (Mar. 6, 2015) According to a report from the CDC, suicide rates among young women increased from 1994 to 2012 while rates among young men have decreased. Video provided by Newsy
Powered by NewsLook.com
Bupa Eyes India Healthcare Opportunities

Bupa Eyes India Healthcare Opportunities

Reuters - Business Video Online (Mar. 5, 2015) Bupa is hoping to expand in India&apos;s fast-growing health insurance market, once a rule change on foreign investment is implemented. The British private healthcare group&apos;s CEO tells Grace Pascoe why it&apos;s so keen on the new opportunity. Video provided by Reuters
Powered by NewsLook.com
Liberia Releases Last Ebola Patient, But Threat Remains

Liberia Releases Last Ebola Patient, But Threat Remains

Newsy (Mar. 5, 2015) Liberia&apos;s last Ebola patient has been released, and the country hasn&apos;t recorded a new case in a week. However, fears of another outbreak still exist. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins