Featured Research

from universities, journals, and other organizations

Rutgers Scientists Post A Genetic Road Map To Sources Of Disease

Date:
July 16, 2003
Source:
Rutgers, The State University Of New Jersey
Summary:
Rutgers geneticist Tara Matise and her colleagues have produced a map that will help pinpoint the genes linked to such serious diseases as diabetes, high blood pressure and schizophrenia.

NEW BRUNSWICK/PISCATAWAY, N.J. – Rutgers geneticist Tara Matise and her colleagues have produced a map that will help pinpoint the genes linked to such serious diseases as diabetes, high blood pressure and schizophrenia.

Related Articles


This linkage map is based on the amount of the interaction or recombination taking place among nearly 3,000 genetic markers whose positions are known. The markers used for the map are single-nucleotide polymorphisms (SNPs) – the variations of a gene that people may carry at one point on their DNA.

A paper describing the linkage map will appear in the August 2003 issue of the American Journal of Human Genetics and is currently available online. Matise is first author on the paper, with Assistant Professor Steven Buyske and graduate student Chunsheng He, both from Rutgers, The State University of New Jersey, also among the authors.

Matise pointed out that SNPs provide a shortcut for pinpointing genes that may contribute to disease because the SNPs are both plentiful and easy to analyze. Many SNPs lie within genes associated with a disease, while others are near such genes, she added.

"Our challenge was to calculate the recombination distance – a measure of interaction – between the markers," said Matise, an associate research professor in the department of genetics. "This is the first map of its kind, a genomewide SNP linkage map, and it provides the kind of data we need to conduct our analyses in the search for disease genes.

"Since our map is much more dense and has more markers than other kinds of maps, we wanted to see how good it really is. We did some calculations to compare the information content of our SNP map versus some existing maps commonly used for genome screening," said Matise. "It turns out that our map is equivalent to or better than the other maps that are currently used."

Matise explained that without this kind of map, SNP-based linkage screening in humans – a procedure by which the entire genome is scanned for evidence of linkage to a disease – cannot be done. This screening is currently performed using specialized and customized high-throughput genotyping machines commercially available from companies including Applied Biosystems, Illumina and Amersham Biosciences.

But in the journal article, Matise and her co-authors wrote, "It is anticipated that the successful identification of a set of SNPs tailored for linkage analysis, such as that presented here, will stimulate development of mass-produced (i.e., less expensive) means for large-scale genotyping with this same marker set."


Story Source:

The above story is based on materials provided by Rutgers, The State University Of New Jersey. Note: Materials may be edited for content and length.


Cite This Page:

Rutgers, The State University Of New Jersey. "Rutgers Scientists Post A Genetic Road Map To Sources Of Disease." ScienceDaily. ScienceDaily, 16 July 2003. <www.sciencedaily.com/releases/2003/07/030716090122.htm>.
Rutgers, The State University Of New Jersey. (2003, July 16). Rutgers Scientists Post A Genetic Road Map To Sources Of Disease. ScienceDaily. Retrieved March 2, 2015 from www.sciencedaily.com/releases/2003/07/030716090122.htm
Rutgers, The State University Of New Jersey. "Rutgers Scientists Post A Genetic Road Map To Sources Of Disease." ScienceDaily. www.sciencedaily.com/releases/2003/07/030716090122.htm (accessed March 2, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 2, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Treadmill Test Can Predict Chance Of Death Within A Decade

Treadmill Test Can Predict Chance Of Death Within A Decade

Newsy (Mar. 2, 2015) Johns Hopkins researchers analyzed 58,000 heart stress tests to come up with a formula that predicts a person&apos;s chances of dying in the next decade. Video provided by Newsy
Powered by NewsLook.com
Going Gluten-Free Could Get You A Tax Break

Going Gluten-Free Could Get You A Tax Break

Newsy (Mar. 2, 2015) If a doctor advises you to remove gluten from your diet, you could get a tax deduction on the amount you spend on gluten-free foods. Video provided by Newsy
Powered by NewsLook.com
GlaxoSmithKline and Novartis Try Swapping Success

GlaxoSmithKline and Novartis Try Swapping Success

Reuters - Business Video Online (Mar. 2, 2015) GlaxoSmithKline and Novartis have completed a series of asset swaps worth more than $20 billion. As Grace Pascoe reports they say the deal will reshape both drugmakers. Video provided by Reuters
Powered by NewsLook.com
How Can West Africa Rebuild After Ebola?

How Can West Africa Rebuild After Ebola?

Reuters - Business Video Online (Mar. 2, 2015) How best to rebuild the three West African countries struggling with Ebola will be discussed in Brussels this week. As Hayley Platt reports Sierra Leone has the toughest job ahead - its once thriving economy has been ravaged by the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins