Featured Research

from universities, journals, and other organizations

Cellular Fat Sensor Slows Heart Disease

Date:
October 17, 2003
Source:
Salk Institute
Summary:
A cellular sensor of dietary fats slows the development of lesions that lead to heart disease, a Salk Institute study has found.

A cellular sensor of dietary fats slows the development of lesions that lead to heart disease, a Salk Institute study has found.

The study, which appears in the Oct. 17 edition of Science and is posted on the journal's web site, uncovers a unique pathway that significantly curbs the development of atherosclerosis - the accumulation of fatty deposits on arterial walls. The pathway could be used to develop drugs to treat heart disease, currently the number one killer of Americans.

Ronald Evans, the March of Dimes Chair in Molecular and Developmental Biology at the Salk Institute, research fellow Chih-Hao Lee and colleagues found that the regulatory molecule, PPAR-delta (short for peroxisome proliferator-activated receptor), plays a powerful part in the body's inflammatory response to the beginning phases of atherosclerosis.

"Immune cells promote inflammation, which stimulates the transport and absorption of fat that triggers the early stages of heart disease," Evans said. "Our study uncovered the molecular switch that regulates this process and reveals how the inflammatory response, designed to fend off invading agents, can go awry and encourage atherosclerosis and heart disease."

The researchers found that the PPAR-delta switch cut heart disease in half. It does this by disrupting a cellular signal that controls the inflammatory response.

Activation of PPAR-delta by a fat-like drug reduces inflammation and discourages the growth of atherosclerotic plaques.

"The lesions that cause atherosclerosis are very complex, and are aggravated," said Evans. "We believe that PPAR-delta normally acts as a molecular soldier to guard against inflammation and disease. Unfortunately, these good effects are compromised by high fat diets, poor exercise, infections and stress. Chemicals that regulate the activity of PPAR-delta could form the basis of a new drug to reduce atherosclerosis and therefore be a possible therapy for heart disease."

Heart disease is the number one health threat to Americans; about one million die from some form of heart disease every year. The Howard Hughes Medical Institute and the National Heart Lung and Blood Institute supported the researchers' work. Evans' collaborators at the Scripps Research Institute include Drs. Linda Curtiss and William Boisvert.

###

The Salk Institute for Biological Studies, located in La Jolla, Calif., is an independent nonprofit organization dedicated to fundamental discoveries in the life sciences, the improvement of human health and conditions, and the training of future generations of researchers. Jonas Salk, M.D., founded the institute in 1960 with a gift of land from the City of San Diego and the financial support of the March of Dimes Birth Defects Foundation.


Story Source:

The above story is based on materials provided by Salk Institute. Note: Materials may be edited for content and length.


Cite This Page:

Salk Institute. "Cellular Fat Sensor Slows Heart Disease." ScienceDaily. ScienceDaily, 17 October 2003. <www.sciencedaily.com/releases/2003/10/031017073109.htm>.
Salk Institute. (2003, October 17). Cellular Fat Sensor Slows Heart Disease. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2003/10/031017073109.htm
Salk Institute. "Cellular Fat Sensor Slows Heart Disease." ScienceDaily. www.sciencedaily.com/releases/2003/10/031017073109.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Newsy (Sep. 30, 2014) The CDC says a new case of Ebola has not been reported in Nigeria for more than 21 days, leading to hopes the outbreak might be nearing its end. Video provided by Newsy
Powered by NewsLook.com
UN Ebola Mission Head: Immediate Action Is Crucial

UN Ebola Mission Head: Immediate Action Is Crucial

AFP (Sep. 30, 2014) The newly appointed head of the United Nations Mission for Ebola Emergency Response (UNMEER), Anthony Banbury, outlines operations to tackle the virus. Duration: 00:39 Video provided by AFP
Powered by NewsLook.com
CDC Confirms First Case of Ebola in US

CDC Confirms First Case of Ebola in US

AP (Sep. 30, 2014) The CDC has confirmed the first diagnosed case of Ebola in the United States. The patient is being treated at a Dallas hospital after traveling earlier this month from Liberia. (Sept. 30) Video provided by AP
Powered by NewsLook.com
New Breast Cancer Drug Extends Lives In Clinical Trial

New Breast Cancer Drug Extends Lives In Clinical Trial

Newsy (Sep. 30, 2014) In a clinical trial, breast cancer patients lived an average of 15 months longer when they received new drug Perjeta along with Herceptin. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins