Featured Research

from universities, journals, and other organizations

Researchers Identify Essential Component Of Immunity Against The Hepatitis C Virus

Date:
October 27, 2003
Source:
Columbus Children's Hospital
Summary:
Researchers at Columbus Children’s Research Institute (CCRI) on the campus of Columbus Children’s Hospital have identified a key component of protective immunity against the hepatitis C virus, the major cause of chronic liver disease and transplantation in the United States.

Researchers at Columbus Children’s Research Institute (CCRI) on the campus of Columbus Children’s Hospital have identified a key component of protective immunity against the hepatitis C virus, the major cause of chronic liver disease and transplantation in the United States. The study found that successful control of hepatitis C infection required close cooperation between two types of white blood cells know as CD4+ “helper” and CD8+ “killer” T lymphocytes. The findings, published in the October 24 issue of Science, indicate that the immune system is unable to eliminate the virus without the CD4+ T lymphocytes.

Related Articles


“Our goal is to understand how a person’s immune response determines the outcome of the hepatitis C infection,” said Christopher M. Walker, Ph.D., director of the Center for Vaccines and Immunity at CCRI on the campus of Columbus Children's Hospital and professor of pediatrics at The Ohio State University College of Medicine and Public Health. “Approximately 70 percent of individuals exposed to hepatitis C become lifelong carriers of the virus. The remaining individuals successfully contain the infection and appear to have long-lasting immunity to the virus. Our finding that CD4+ T helper cells are essential for this protection move us one step closer to developing an effective vaccine for hepatitis C,” he added.

There are 170 million people around the world (including 4 million in the United States) infected with the hepatitis C virus. Most of these people don’t know they are chronic carriers of the virus until they develop liver problems.

The study, conducted in an animal model of human hepatitis C infection, demonstrated that temporary depletion of the CD4+ T helper cells abolished protective immunity against a second infection with the virus. The CD8+ T killer lymphocytes alone were an ineffective defense as the virus rapidly mutated to evade this immune response.

“Vaccines are the most cost-effective way to contain viruses like hepatitis C and with these findings, we move one step closer to that goal,” added Dr. Walker.


Story Source:

The above story is based on materials provided by Columbus Children's Hospital. Note: Materials may be edited for content and length.


Cite This Page:

Columbus Children's Hospital. "Researchers Identify Essential Component Of Immunity Against The Hepatitis C Virus." ScienceDaily. ScienceDaily, 27 October 2003. <www.sciencedaily.com/releases/2003/10/031027064057.htm>.
Columbus Children's Hospital. (2003, October 27). Researchers Identify Essential Component Of Immunity Against The Hepatitis C Virus. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2003/10/031027064057.htm
Columbus Children's Hospital. "Researchers Identify Essential Component Of Immunity Against The Hepatitis C Virus." ScienceDaily. www.sciencedaily.com/releases/2003/10/031027064057.htm (accessed March 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins