Featured Research

from universities, journals, and other organizations

UCLA Study Identifies Stem Cell In Artery Wall

Date:
October 28, 2003
Source:
University Of California - Los Angeles
Summary:
A UCLA study demonstrates for the first time that specific cells found in the adult artery wall have stem cell-like potential. Researchers found artery cells that change into cartilage, bone, muscle and marrow stromal cells.

A UCLA study demonstrates for the first time that specific cells found in the adult artery wall have stem cell-like potential. Researchers found artery cells that change into cartilage, bone, muscle and marrow stromal cells.

The new study will be published online on Oct. 27 and will appear in an upcoming print issue of the journal Circulation. The study may lead to a new source of adult stem cells, which may increase potential treatment options and avoid the controversial use of fetal stem cells.

"This is the first study to show that cells in the artery wall have the potential to develop into a number of other cell types," said Dr. Linda Demer, principal investigator, Guthman Professor of Medicine and Physiology, and vice chair for cardiovascular and vascular medicine at the David Geffen School of Medicine at UCLA.

UCLA researchers also report that the artery wall cells, called calcifying vascular cells (CVC), are the only cells other than actual bone marrow stromal cells that support survival of immature (developing) blood cells. This finding may have future applications in reconstitution of bone marrow after cancer treatment.

UCLA researchers cultured bovine CVC artery wall cells in the lab to see if the cells would turn into bone, fat, cartilage, marrow and muscle cells. They checked for expression of proteins and tissue matrix characteristic of each cell type.

"We wanted to see if CVC cells would become specific cell types that actually produce their own characteristic matrix (mortar-like) substance. For example, if the cell actually produced bone mineral, it would indicate that the cell had taken on a bone identity," said first author Yin Tintut, Division of Cardiology at the David Geffen School of Medicine at UCLA.

Researchers found that CVC cells had the potential to become several cell types, including bone, cartilage, marrow stromal and muscle cells, but not adipogenic, or fat, cells. Demer suggests this indicates that the CVC cells may not have the entire range of conventional stem cells. However, this may be especially useful in cases where one would not want the stem cell turning into a fat cell -- such as in trying to regenerate cartilage.

The next step involves "assessing CVC cells' potential to follow other lineages and also testing human cells," Demer said.

Stem cells are young, uncommitted cells with the ability to regenerate more stem cells and to differentiate into a variety of cell types. Researchers can then grow cells in the lab and program them to make specific tissue that may be used to repair damaged tissues such as in reconstructive surgery.

Two institutes that are part of the National Institutes of Health funded the study: the National Heart, Lung and Blood Institute, and the National Institute of Arthritis, Musculoskeletal and Skin Diseases.

Other researchers include Zeni Alfonso from the UCLA department of urology; and Trishal Saini, Kristen Radcliff, Dr. Karol Watson and Dr. Kristina Bostrφm from the UCLA department of medicine.


Story Source:

The above story is based on materials provided by University Of California - Los Angeles. Note: Materials may be edited for content and length.


Cite This Page:

University Of California - Los Angeles. "UCLA Study Identifies Stem Cell In Artery Wall." ScienceDaily. ScienceDaily, 28 October 2003. <www.sciencedaily.com/releases/2003/10/031028055002.htm>.
University Of California - Los Angeles. (2003, October 28). UCLA Study Identifies Stem Cell In Artery Wall. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2003/10/031028055002.htm
University Of California - Los Angeles. "UCLA Study Identifies Stem Cell In Artery Wall." ScienceDaily. www.sciencedaily.com/releases/2003/10/031028055002.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) — Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) — Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) — Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) — Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins