Featured Research

from universities, journals, and other organizations

New TB Vaccine Shows Promise In HIV Infection

Date:
November 7, 2003
Source:
Dartmouth Medical School
Summary:
An innovative vaccine against tuberculosis has shown promise in persons with HIV, researchers from Dartmouth Medical School and the National Public Health Institute of Finland report in the Nov. 7 issue of the journal AIDS.

HANOVER, NH – An innovative vaccine against tuberculosis has shown promise in persons with HIV, researchers from Dartmouth Medical School and the National Public Health Institute of Finland report in the Nov. 7 issue of the journal AIDS.

Related Articles


An international team led by DMS infectious disease expert Dr. C. Fordham von Reyn, professor of medicine, found that the new booster, a killed vaccine, enhanced the TB immunity of HIV patients. Their weakened immune systems make the current TB vaccine, which is a live vaccine, more risky.

In most countries where TB is widespread, children generally receive a vaccine made from live Mycobacterium bovis, Bacille Calmette-Guerin (BCG) that has been used to reduce the risk of TB for more than half century. Despite the widespread use of BCG, TB has been growing dramatically in the world, fueled by the increased susceptibility of HIV-infected people to TB.

TB remains the largest cause of death worldwide from any single infectious disease, according to the National Institute of Allergy and Infectious Diseases, which calls it "the major attributable cause of death" in HIV/AIDS patients.

"Since there is no evidence that the current BCG vaccine protects patients with HIV against TB, we have been working on a new strategy to immunize persons with HIV against TB, safely and effectively," said von Reyn.

In a "back to the future" approach, the investigators revived a strategy used successfully prior to BCG: administration of killed vaccines against TB. The DMS-led team dusted off the concept to employ a multiple dose series of a contemporary killed mycobacterial vaccine to prevent TB in a particularly vulnerable and ever growing group of patients.

The study was done in Finland where BCG vaccine is routinely administered at birth. A cohort of 39 HIV patients, mainly men, were divided into two groups to receive a five-dose course of the killed vaccine, Mycobacterium vaccae, or a control vaccine for Hepatitis B. Parallel studies were also conducted on HIV- negative subjects.

"The multiple-dose course of the inactivated vaccine boosted immunity against TB both in those with HIV and those without TB," von Reyn said. "The vaccine was also safe and did not adversely affect the patients' underlying HIV infection."

The study served as the basis for a large-scale trial Dartmouth researchers have been conducting since 2001 in Dar es Salaam, Tanzania with Muhimbili Hospital Medical Center. The five-year $3 million NIH funded study is the only efficacy trial of a new TB vaccine currently under way in the world. The Tanzania trial will enroll more than 2000 HIV-infected patients to determine if the boosted immunity detected in the Finnish study actually reduces the risk of tuberculosis among HIV infected people in Tanzania at high risk of the disease.

First author of the article is Dr. Jenni Vuola of the National Public Health Institute of Finland. Co-authors include Dr. Matti Ristola from Helsinki University Central Hospital, Dr. Bernard Cole, associate professor of community and family medicine at DMS and Susan Tvaroha at DMS. The M. vaccae vaccine is produced by SR Pharma in London.


Story Source:

The above story is based on materials provided by Dartmouth Medical School. Note: Materials may be edited for content and length.


Cite This Page:

Dartmouth Medical School. "New TB Vaccine Shows Promise In HIV Infection." ScienceDaily. ScienceDaily, 7 November 2003. <www.sciencedaily.com/releases/2003/11/031107055135.htm>.
Dartmouth Medical School. (2003, November 7). New TB Vaccine Shows Promise In HIV Infection. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2003/11/031107055135.htm
Dartmouth Medical School. "New TB Vaccine Shows Promise In HIV Infection." ScienceDaily. www.sciencedaily.com/releases/2003/11/031107055135.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) — The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins