Featured Research

from universities, journals, and other organizations

Wound-healing Genes Influence Cancer Progression, Say Stanford Researchers

Date:
January 13, 2004
Source:
Stanford University Medical Center
Summary:
Genes that help wounds heal are most often the "good guys," but a new study paints them as the enemy in some types of cancer. Researchers at the Stanford University School of Medicine have found that some tumors activate these wound-healing genes and, when they do, the tumors are more likely to spread. This work could help highlight new ways to treat the disease along with helping doctors decide which cancers to approach more aggressively.

STANFORD, Calif. - Genes that help wounds heal are most often the "good guys," but a new study paints them as the enemy in some types of cancer. Researchers at the Stanford University School of Medicine have found that some tumors activate these wound-healing genes and, when they do, the tumors are more likely to spread. This work could help highlight new ways to treat the disease along with helping doctors decide which cancers to approach more aggressively.

Related Articles


"This is a feature we can find early on in the disease and it could change the way cancer is treated," said Howard Chang, MD, PhD, a postdoctoral scholar and lead author of the paper. The work appears in the Jan. 19 edition of Public Library of Science Biology.

The research group, led by Patrick Brown, MD, PhD, professor of biochemistry, took an unusual approach in finding the telltale genes. In most studies, scientists analyze tumor samples and look for genes that are more active compared to normal tissue. Such studies have produced long lists of genes involved in cancer biology but don't provide clues about what role those genes may be playing.

Chang started from the opposite direction. He knew wound healing and cancer progression had some similarities, including the growth of new blood vessels, rearrangement of the molecular matrix around the cells and changes in how cells attach to each other. "Wound healing is a process that allows cells to break normal constraints on their growth and cross boundaries. If a cell can access that program, that's a good environment for cancer," Chang said.

The researchers started by finding which genes are active in cells exposed to clotted blood as a model of cells in the wound-healing process. Then Chang and his colleagues looked to see whether those same genes were active in tumor samples.

The researchers found that prostate and liver cancers always activated wound-healing genes, while tumors in the breast, colon and prostate were mixed. In these variable tissues, tumors with active wound-healing genes turned out to be highly aggressive and were more likely to spread to other tissues.

Chang said assessing wound-healing genes could help doctors choose the best treatment for a patient. "There are a lot of drugs that work only on certain type of cancers. If you realize that different drugs work on a specific abnormality, doctors can match the drug to the problem," he said.

The best-known example of such pharmaceutical matchmaking is the drug Herceptin, which specifically treats breast cancers with an active version of the gene Her2/Neu.

Most doctors don't have the ability to screen tumor samples for active genes, but they routinely test for the presence of proteins made by genes, as with Her2/Neu. Julie Sneddon, a biochemistry graduate student and second author on the paper, has been working on a similar test to identify tumors that churn out wound-healing proteins.

Chang said the next step is learning how best to treat tumors that produce these proteins. Because wound healing is a well-understood process, researchers may be able to disrupt the process and slow the cancer's spread. "There are drugs coming out that block blood vessel growth, so perhaps those drugs should be targeted to this population of patients," Chang said.

Additional Stanford researchers who contributed to this work include postdoctoral scholars Ruchira Sood, PhD, and Jen-Tsan Chi, MD, PhD; Ash Alizadeh, MD, PhD, a former graduate student; Rob West, MD, PhD, clinical instructor of pathology; Kelli Montgomery, research associate; and Matt van de Rijn, MD, PhD, associate professor of pathology.

###

Stanford University Medical Center integrates research, medical education and patient care at its three institutions - Stanford University School of Medicine, Stanford Hospital & Clinics and Lucile Packard Children's Hospital at Stanford. For more information, please visit the Web site of the medical center's Office of Communication & Public Affairs at http://mednews.stanford.edu.


Story Source:

The above story is based on materials provided by Stanford University Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Stanford University Medical Center. "Wound-healing Genes Influence Cancer Progression, Say Stanford Researchers." ScienceDaily. ScienceDaily, 13 January 2004. <www.sciencedaily.com/releases/2004/01/040113075324.htm>.
Stanford University Medical Center. (2004, January 13). Wound-healing Genes Influence Cancer Progression, Say Stanford Researchers. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2004/01/040113075324.htm
Stanford University Medical Center. "Wound-healing Genes Influence Cancer Progression, Say Stanford Researchers." ScienceDaily. www.sciencedaily.com/releases/2004/01/040113075324.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins