Featured Research

from universities, journals, and other organizations

Predicting Progression Of Common Cancers

Date:
January 14, 2004
Source:
Public Library Of Science
Summary:
In an effort to create a framework for evaluating the relationship between tumor and wounds, Howard Chang and his colleagues in Patrick Brown's lab at Stanford University examined the gene expression profile of fibroblasts responding to serum in cell culture--a process that shares certain features with wound healing.

The idea that cancer cells go through a fateful transition that turns them into fast-growing, invasive, metastasizing tumors first surfaced in the early 1970s. By the mid-1980s histological analysis revealed a similarity between the tumor "microenvironment" and that of a healing wound, prompting Harvard pathologist Harold Dvorak to describe cancer as a wound that does not heal. With no systematic method to measure the "wound-like" features in cancer, however, scientists had no way to evaluate the risk that a wound-healing genetic program may pose in cancer progression.

Related Articles


In an effort to create a framework for evaluating the relationship between tumor and wounds, Howard Chang and his colleagues in Patrick Brown's lab at Stanford University examined the gene expression profile of fibroblasts responding to serum in cell culture--a process that shares certain features with wound healing. Fibroblasts are involved in wound healing, and serum is encountered in the body where blood leaks out of blood vessels (such as sites of injury), and is thought to be a major initiator of the wound-healing response.

Though fibroblasts from different sites in the body differ in their properties and gene expression profiles, Brown and colleagues found that they share a common expression pattern in response to serum. From this expression profile, Chang et al. identified a core group of genes--a genetic signature--associated with a serum response. Because many of the genes in the signature were known to be involved in various wound-healing processes--such as matrix remodeling, cell motility, and angiogenesis--Chang et al. used this signature as a surrogate marker to measure how much tumors may be like wounds. When they compared the wound-like genetic signature with the expression profiles of various clinical tumor samples, they found the signature was always present in certain cancers--prostate and liver cell carcinomas--and occurred variably in others--breast, lung, and gastric carcinomas. In each of these three latter types of tumors, patients with tumors carrying the serum-activated wound-like genetic signature had a significantly increased risk of metastasis and death compared to patients with tumors that lacked the signature.

These results reveal a similarity between the molecular programs in normal wound healing and tumor progression and metastasis and suggest that a wound-like phenotype is a general risk factor for metastasis and aggressive behavior in many of the most common cancers. And the serum-response expression signature provides a valuable new diagnostic tool for predicting tumor behavior and determining a patient's prognosis.


Story Source:

The above story is based on materials provided by Public Library Of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library Of Science. "Predicting Progression Of Common Cancers." ScienceDaily. ScienceDaily, 14 January 2004. <www.sciencedaily.com/releases/2004/01/040114075746.htm>.
Public Library Of Science. (2004, January 14). Predicting Progression Of Common Cancers. ScienceDaily. Retrieved November 20, 2014 from www.sciencedaily.com/releases/2004/01/040114075746.htm
Public Library Of Science. "Predicting Progression Of Common Cancers." ScienceDaily. www.sciencedaily.com/releases/2004/01/040114075746.htm (accessed November 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

UN Says It Will Scale Up Its Ebola Response

UN Says It Will Scale Up Its Ebola Response

AFP (Nov. 20, 2014) UN Resident Coordinator David McLachlan-Karr and WHO representative in the country Daniel Kertesz updated the media on the UN Ebola response on Wednesday. Duration: 00:51 Video provided by AFP
Powered by NewsLook.com
Takata Offers "sincerest Condolences" To Victims of Malfunctioning Airbag

Takata Offers "sincerest Condolences" To Victims of Malfunctioning Airbag

Reuters - US Online Video (Nov. 20, 2014) U.S. Congress hears from a victim and company officials as it holds a hearing on the safety of Takata airbags after reports of injuries. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Obesity Costs Almost As Much As War And Terrorism

Obesity Costs Almost As Much As War And Terrorism

Newsy (Nov. 20, 2014) The newest estimate of the cost of obesity is pretty jarring — $2 trillion. But how did researchers get to that number? Video provided by Newsy
Powered by NewsLook.com
Ebola Crisis Affecting US Adoptions

Ebola Crisis Affecting US Adoptions

AP (Nov. 20, 2014) The Sanborn family had hoped they'd be able to bring home their 5-year-old adopted son from Liberia by now. But Ebola has forced them to wait. The boy is just one of thousands of orphans in West Africa who've been impacted by the deadly virus. (Nov. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins