Featured Research

from universities, journals, and other organizations

Combining Surgery With Novel Treatment May Improve Survival Rates

Date:
February 16, 2004
Source:
Wake Forest University Baptist Medical Center
Summary:
Researchers at Wake Forest University Baptist Medical Center report in the February issue of Annals of Surgical Oncology that surgery combined with inserting heated chemotherapy drugs directly into the abdomen can improve survival rates and quality of life in patients with cancer of the abdominal cavity that has spread from the colon.

Winston-Salem, N.C. – Researchers at Wake Forest University Baptist Medical Center report in the February issue of Annals of Surgical Oncology that surgery combined with inserting heated chemotherapy drugs directly into the abdomen can improve survival rates and quality of life in patients with cancer of the abdominal cavity that has spread from the colon.

Related Articles


Patients participating in the research study had a median overall survival of 16 months, with 17 percent surviving five years or more. Traditionally, patients with this condition, called peritoneal carcinomatosis, survive only 3 to 6 months without treatment.

Peritoneal cancer is the most common cause of death in patients with cancers in the abdomen. Surgery alone has proven to be ineffective, as have external beam radiation therapy, brachytherapy and systemic chemotherapy.

Perry Shen, M.D., assistant professor of surgical oncology, was lead author of the study, which involved a retrospective review of 77 patients between 1991 and 2002 with peritoneal disease that had spread from colorectal cancer.

"As surgical techniques and perioperative care have improved, there has been a greater trend towards more aggressive surgical treatment of solid tumors," said Shen. "This study, combined with reports from other institutions, indicates that selected patients can achieve long- term survival with complete removal of peritoneal disease from colorectal cancer, which is the second leading cause of cancer death in the United States."

All patients underwent surgery to remove as much of the tumor and surrounding cancerous tissue as possible, followed immediately with a treatment called intraperitoneal hyperthermic chemotherapy (IPHC). With IPHC, the patient's core temperature was cooled to just over 93 degrees Fahrenheit. Immediately after surgery, catheters were placed in the abdomen to deliver the chemotherapy directly into the abdominal cavity. The chemotherapy agent, heated to a maximum temperature of 105 degrees Fahrenheit, was delivered through the catheters. The abdomen was gently massaged throughout the two-hour procedure to improve drug distribution.

Delivering chemotherapy in this manner has the benefit of getting higher concentrations of the drug directly to the site of the tumor while minimizing toxicity to the rest of the body.

Experimental evidence suggests that tumor tissue is more sensitive to heat than normal tissue and has less resistance to chemotherapy when the temperature of the drug is raised.

Since IPHC is essentially a palliative procedure, alleviating the symptoms without curing the disease, an important factor to consider besides overall survival is the effect of the procedure on the patient's quality of life. The quality of life was preserved for the majority of patients, both in the short term and long term.

"A prospective randomized study in Europe recently reported the benefit of intraperitoneal heated chemotherapy compared to surgery and systemic chemotherapy alone. A larger, phase III prospective trial is planned," said Shen. "Although it is clearly not a treatment for all patients with peritoneal cancer, selected patients may benefit from improved quality of life and extended survival," he said.


Story Source:

The above story is based on materials provided by Wake Forest University Baptist Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Wake Forest University Baptist Medical Center. "Combining Surgery With Novel Treatment May Improve Survival Rates." ScienceDaily. ScienceDaily, 16 February 2004. <www.sciencedaily.com/releases/2004/02/040212085309.htm>.
Wake Forest University Baptist Medical Center. (2004, February 16). Combining Surgery With Novel Treatment May Improve Survival Rates. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2004/02/040212085309.htm
Wake Forest University Baptist Medical Center. "Combining Surgery With Novel Treatment May Improve Survival Rates." ScienceDaily. www.sciencedaily.com/releases/2004/02/040212085309.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins