Featured Research

from universities, journals, and other organizations

New Device To Be Tested On Patients With Major Depression

Date:
February 12, 2004
Source:
Wake Forest University Baptist Medical Center
Summary:
Transcranial Magnetic Stimulation (TMS), a technique that uses repeated short bursts of magnetic energy to stimulate nerve cells in the brain, will soon be tested at Wake Forest University Baptist Medical Center as a treatment for major depression.

WINSTON-SALEM, N.C. – Transcranial Magnetic Stimulation (TMS), a technique that uses repeated short bursts of magnetic energy to stimulate nerve cells in the brain, will soon be tested at Wake Forest University Baptist Medical Center as a treatment for major depression.

Wake Forest Baptist will be one of 16 centers participating in the national clinical trial to compare TMS with a "sham" treatment in patients with major depression.

Smaller preliminary studies have indicated that TMS has an antidepressant effect, but this larger, more rigorous trial is necessary to better understand the strength of the effect and gain U.S. Food and Drug Administration (FDA) clearance for use, said Peter Rosenquist, M.D., principal investigator at Wake Forest.

“If cleared by the FDA, TMS could be a significant new weapon for doctors to offer patients fighting depression,” he said. Major depression, which affects an estimated 13 million Americans, is characterized by such symptoms as inability to concentrate, insomnia, loss of appetite, inability to experience pleasure, and feelings of sadness, guilt, hopelessness and helplessness.

Rosenquist, associate professor of psychiatry and behavioral medicine, explained that the sham treatment is needed because some patients improve simply because of the added attention they get in a research study, the so-called placebo effect. Comparison with the sham treatment will confirm whether TMS really works.

The new trial, involving 286 patients nationally, will be a pivotal trial, and if the results are positive, the data will be submitted to the U.S. Food and Drug Administration for approval of TMS as a treatment for major depression.

Rosenquist said that neither doctor nor patient will know whether the actual TMS is being used. The sham device looks, acts and sounds like the real thing.

TMS produces about the same amount of magnetic energy as a standard MRI machine, but instead of helping doctors look inside the body, the pulses of magnetic energy are aimed at a portion of the brain called the left prefrontal cortex, which is involved with mood regulation.

The magnetic pulses easily pass through the skull and into the brain. Inside the brain, Rosenquist said, the magnetic pulses produce an electric field, which can cause positive changes in mood. Patients remain fully awake during the 45 minute outpatient TMS procedure and can immediately go back to their normal daily activities.

“The amount of electricity created in the brain is kept small enough to minimize the risk of adverse effects,” Rosenquist said. Those effects sometimes include headache and, in rare cases, a seizure.

A similar Transcranial Magnetic Stimulation device is already in use for brain mapping, diagnosis of neurological diseases and research into a number of neurological and psychiatric conditions.

Rosenquist said that typical ways of treating major depression include antidepressants and other pharmaceuticals, electroconvulsive therapy, and several methods of psychotherapy. The study will focus on those patients who have not responded to several trials of antidepressant medications.

“We are excited to be participating in this landmark research for a new antidepressant,” Rosenquist said.

The study is being sponsored by the manufacturer of the TMS equipment, Neuronetics, a medical device company headquartered in Malvern, Pa.


Story Source:

The above story is based on materials provided by Wake Forest University Baptist Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Wake Forest University Baptist Medical Center. "New Device To Be Tested On Patients With Major Depression." ScienceDaily. ScienceDaily, 12 February 2004. <www.sciencedaily.com/releases/2004/02/040212085356.htm>.
Wake Forest University Baptist Medical Center. (2004, February 12). New Device To Be Tested On Patients With Major Depression. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2004/02/040212085356.htm
Wake Forest University Baptist Medical Center. "New Device To Be Tested On Patients With Major Depression." ScienceDaily. www.sciencedaily.com/releases/2004/02/040212085356.htm (accessed July 25, 2014).

Share This




More Mind & Brain News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins