Featured Research

from universities, journals, and other organizations

What Are Your Odds Of Surviving Into Your Hundreds?

Date:
February 18, 2004
Source:
BioMed Central
Summary:
A genetic factor that protects you against heart disease during middle age could reduce the odds that you’ll celebrate your hundredth birthday. Research published in BMC Medical Genetics shows that a genetic trait, which is rarely found in centenarians, is associated with lower cholesterol levels.

A genetic factor that protects you against heart disease during middle age could reduce the odds that you’ll celebrate your hundredth birthday. Research published in BMC Medical Genetics shows that a genetic trait, which is rarely found in centenarians, is associated with lower cholesterol levels.

Related Articles


The risk of suffering from heart disease is increased by a number of factors, including having high levels of low-density lipoprotein cholesterol in your blood. The main component of low-density lipoprotein is apoliprotein (b) whose quality and quantity are related to the quality and expression of the APOB genes you have.

In a previous study, Professor Giovanna De Benedictis found that older, healthy people were most unlikely to carry short versions of a DNA region that neighbours the APOB gene. “This indicates that the short alleles are unfavourable to longevity,” she says. In contrast, these short versions are over-represented in healthy, middle-aged adults, indicating that these variants of the APOB gene region play a protective role at this point in your life.

Her group have now analysed both the variability in the DNA surrounding the APOB gene and the low-density lipoprotein cholesterol levels in over 400 healthy volunteers, between the ages of 20 and 102. The aim was to see if there was any link between the two factors.

Their results show that people with short variants of the APOB gene region have significantly lower levels of total cholesterol and low-density lipoprotein cholesterol in their blood.

The authors of the study write: “On the whole, the short alleles would be advantageous in adults, by protecting them from high levels of LDL-Cholesterol, while dangerous in the elderly, probably by lowering serum cholesterol below a critical threshold.”

In line with these findings, the researchers showed that patients suffering from heart disease as a consequence of having high low-density lipoprotein cholesterol levels were less likely to have one or more short variants of the APOB gene region, compared to healthy volunteers.

“On the whole, the study confirms that genetic risk factors are age-specific and gives possible insights into another ‘paradox of centenarians’,” write the authors.

###

This press release is based on the following article:

A study of the average effect of the 3'APOB-VNTR polymorphism on lipidemic parameters could explain why the short alleles (<35 repeats) are rare in centenarians.S Garasto, M Berardelli, F De Rango, V Mari, E Geraco and G De BenedictisBMC Medical Genetics, 2004 5:3Published 9 February, 2004

This article is freely available, according to BMC Medical Genetics’ Open Access policy at: http://www.biomedcentral.com/1471-2350/5/3/

BMC Medical Genetics (http://www.biomedcentral.com/bmcmedgenet) is published by BioMed Central (http://www.biomedcentral.com), an independent online publishing house committed to providing Open Access to peer-reviewed biological and medical research. This commitment is based on the view that immediate free access to research and the ability to freely archive and reuse published information is essential to the rapid and efficient communication of science. BioMed Central currently publishes over 100 journals across biology and medicine. In addition to open-access original research, BioMed Central also publishes reviews, commentaries and other non-original-research content. Depending on the policies of the individual journal, this content may be open access or provided only to subscribers.


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Cite This Page:

BioMed Central. "What Are Your Odds Of Surviving Into Your Hundreds?." ScienceDaily. ScienceDaily, 18 February 2004. <www.sciencedaily.com/releases/2004/02/040218080337.htm>.
BioMed Central. (2004, February 18). What Are Your Odds Of Surviving Into Your Hundreds?. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2004/02/040218080337.htm
BioMed Central. "What Are Your Odds Of Surviving Into Your Hundreds?." ScienceDaily. www.sciencedaily.com/releases/2004/02/040218080337.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Americans Drink More in the Winter

Americans Drink More in the Winter

Buzz60 (Dec. 22, 2014) The BACtrack breathalyzer app analyzed Americans' blood alcohol content and found out a whole lot of interesting things about their drinking habits. Mara Montalbano (@maramontalbano) has more. Video provided by Buzz60
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins