Featured Research

from universities, journals, and other organizations

Young People Prone To Type 2 Diabetes Exhibit Alterations In Mitochondrial Activity

Date:
February 23, 2004
Source:
Yale University
Summary:
Researchers at Yale have found that decreased activity in muscle mitochondria, the powerhouses of the cell, may be a major factor in the development of type 2 diabetes in young, lean offspring of parents with the disease.

Researchers at Yale have found that decreased activity in muscle mitochondria, the powerhouses of the cell, may be a major factor in the development of type 2 diabetes in young, lean offspring of parents with the disease.

They demonstrated a potential mechanism for the accumulation of fat in muscle cells of young, lean, insulin-resistant children of parents with type 2 diabetes by comparing them with insulin-sensitive control subjects matched for age, weight, height and activity.

"There is a strong relationship between lipid content in the muscle and insulin resistance in skeletal muscle," said principal investigator Gerald I. Shulman, M.D., professor of internal medicine and cellular & molecular physiology at Yale School of Medicine. "Insulin resistance is the best predictor for whether someone will eventually develop type 2 diabetes."

Using proton magnetic resonance spectroscopy (MRS), a safe, noninvasive method that does not involve any ionizing radiation, researchers found that insulin resistance in muscle of the diabetic offspring was accompanied by an increase in muscle cell lipid content.

Shulman, an investigator at the Howard Hughes Medical Institute, led his group to distinguish whether the increase in muscle cell triglycerides was the result of increased delivery of fatty acids to muscle cells from the fat stored in "fat cells" (adipocytes), or the result of a decreased rate of fat oxidation by the mitochondria in the muscle cells. They measured rates of fatty acid release from adipocytes and found no differences between the two groups. In contrast, using phosphorus MRS they found a 30 percent reduction in the rate of mitochondrial energy production in the muscle of insulin resistant subjects compared to the control group.

"These data support the hypothesis that insulin resistance in young, lean, healthy insulin resistant offspring of patients with type 2 diabetes may be due to an inherited defect that causes decreased mitochondrial activity and predisposes them to accumulate fat inside their muscle cells and develop insulin resistance," said Shulman.

Shulman and his team are now investigating whether the decrease is due to a reduced number of mitochondria and/or reduced mitochondrial function and whether these abnormalities can be reversed with exercise training.

"These results support the hypothesis that nuclear encoded genes that regulate mitochondrial biogenesis may be an important genetic cause of type 2 diabetes and that mitochondrial biogenesis represents a novel therapeutic target for treatment and possible prevention of type 2 diabetes," said Shulman.

Other authors on the study included Kitt Falk Petersen, M.D., assistant professor of internal medicine at Yale; Sylvie Dufour, Douglas Befroy and Rina Garcia.


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Young People Prone To Type 2 Diabetes Exhibit Alterations In Mitochondrial Activity." ScienceDaily. ScienceDaily, 23 February 2004. <www.sciencedaily.com/releases/2004/02/040223074147.htm>.
Yale University. (2004, February 23). Young People Prone To Type 2 Diabetes Exhibit Alterations In Mitochondrial Activity. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2004/02/040223074147.htm
Yale University. "Young People Prone To Type 2 Diabetes Exhibit Alterations In Mitochondrial Activity." ScienceDaily. www.sciencedaily.com/releases/2004/02/040223074147.htm (accessed September 20, 2014).

Share This



More Health & Medicine News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins