Featured Research

from universities, journals, and other organizations

Rich Genes Travel More

Date:
March 4, 2004
Source:
RIKEN Center For Developmental Biology
Summary:
Hiroki R. Ueda of the RIKEN Center for Developmental Biology (Kobe, Japan) and colleagues report their discovery of a fundamental governing principle to the dynamics capable of producing the heterogeneous distribution of gene expression.

In a study of changes in gene expression covering taxa from bacteria to human published in the PNAS Online Early Edition issue of the Proceedings of the National Academy of Sciences, Hiroki R. Ueda of the RIKEN Center for Developmental Biology (Kobe, Japan) and colleagues report their discovery of a fundamental governing principle to the dynamics capable of producing the heterogeneous distribution of gene expression.

Ueda, who heads the CDB Laboratory for Systems Biology, found that changes in gene expression scaled closely with initial expression levels in every organism studied; highly expressed genes tend to change in a highly dynamic way, while genes with lower expression levels are less likely to show such variability. Such proportionality governs many forms of expression changes, such as temporal oscillations, responses to environmental stimuli and developmentally determined or tissue-specific gene regulation, and underlies the heterogeneous distribution of gene expression. The distribution of gene expression can be described using what is known as a ?gpower law?h distribution. In such a system, it can be shown that the number of genes having expression level X is 100 times larger than that of the population having a tenfold greater expression level (10X).

The basic dynamics that underlie and produce this power-law distribution have yet to be worked out, but Ueda and colleagues now propose that the proportional dynamic operating in gene expression changes might be described as a "rich-travel-more" mechanism, a counter concept to the "rich-get-richer" metaphor that has been used to explain other power law-based distributions, such as the growth of network connections in the World Wide Web.

The PNAS study looked at gene expression dynamics in a broad range of model organisms familiar to life sciences researchers, including the intestinal bacteria E. coli, the yeast S. cerevisiae, Arabidopsis thaliana (thale cress), the fruit fly Drosophila melanogaster, mouse and human, by studying genome-wide RNA expression change using GeneChip microarrays. The team?fs analysis of distribution of gene expression in diverse species revealed that there is an apparently universal principle in expression dynamics, and showed that this principle can generate the observed heterogeneous power-law distribution of gene expression. These findings dovetail nicely with other ongoing studies that indicate a similar mechanism is at work in the evolution of metabolic networks, and point the way toward an improved understanding of the systems-level features capable of generating complex and dynamic biological network structures.


Story Source:

The above story is based on materials provided by RIKEN Center For Developmental Biology. Note: Materials may be edited for content and length.


Cite This Page:

RIKEN Center For Developmental Biology. "Rich Genes Travel More." ScienceDaily. ScienceDaily, 4 March 2004. <www.sciencedaily.com/releases/2004/03/040304071844.htm>.
RIKEN Center For Developmental Biology. (2004, March 4). Rich Genes Travel More. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2004/03/040304071844.htm
RIKEN Center For Developmental Biology. "Rich Genes Travel More." ScienceDaily. www.sciencedaily.com/releases/2004/03/040304071844.htm (accessed April 20, 2014).

Share This



More Health & Medicine News

Sunday, April 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins