Featured Research

from universities, journals, and other organizations

Chromosome Losses Mean Poor Survival In Childhood Leukemia

Date:
May 13, 2004
Source:
Ohio State University
Summary:
A new international study of children with a severe form of acute lymphoblastic leukemia (ALL) shows that certain chromosome losses can signal an especially poor response to therapy, but that other chromosome abnormalities have no effect on treatment survival.

COLUMBUS, Ohio – A new international study of children with a severe form of acute lymphoblastic leukemia (ALL) shows that certain chromosome losses can signal an especially poor response to therapy, but that other chromosome abnormalities have no effect on treatment survival.

Related Articles


The finding should enable doctors to identify patients with severe ALL for additional or experimental therapies when such therapies become available. The study was published in the April issue of the journal Leukemia.

“Overall, we found that many chromosome abnormalities in our group of patients made no difference at all, although particular abnormalities could,” says Dr. Nyla A. Heerema, a researcher with The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, and first author on the study.

“The results surprised us,” she says. “We expected that additional chromosome abnormalities would mean a worse outcome.”

The retrospective study involved 249 children diagnosed with ALL between 1986 and 1996 by 10 medical centers in the United States and five other countries. The children had received intensive chemotherapy and their disease had gone into complete remission.

All the children had cancers showing the Philadelphia chromosome, an alteration in the genes that indicates a poorer response to treatment. Sixty-one percent of the patients (153), showed secondary chromosome abnormalities; that is, abnormalities present in addition to the Philadelphia chromosome.

Heerema and her colleagues wanted to learn if secondary chromosome abnormalities contributed to a poor prognosis in children with ALL. They found that having most secondary chromosome abnormalities had little affect on a child’s prognosis. It did, however, when they involved the loss of chromosome 7, or the part of it known as 7p, or the loss of a part of chromosome 9 known as 9p.

Among children with cancer cells that were missing one or both of these, only 15 percent were still disease-free five years after entering remission.

On the other hand, 31 to 43 percent of children with intact chromosomes 7 and 9 remained disease-free at five years. That rate held true even when other chromosome abnormalities were present.Surprisingly, cases of this kind of leukemia that showed a second Philadelphia chromosome also did better than all cases combined. ALL is the most common childhood leukemia, and it accounts for about one-fifth of all acute leukemias in adults. About 80 percent of children with ALL have a curable form of the disease, while the others respond less well to therapy, sometimes depending on which chromosome changes are present.

The Philadelphia chromosome, which occurs in 2 to 5 percent of children with ALL, is an abnormal chromosome that sometimes occurs in several types of childhood and adult leukemias. It arises when a piece of chromosome 9 fuses with a chromosome 22. The fusion results in an abnormal protein that plays an important role in the malignancy.

Grants from the National Cancer Institute and from the governments of participating countries supported this research.

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute is a founding member of the National Comprehensive Cancer Network. The James Cancer Hospital is consistently ranked by U.S. News & World Report as one of America’s best cancer hospitals.


Story Source:

The above story is based on materials provided by Ohio State University. Note: Materials may be edited for content and length.


Cite This Page:

Ohio State University. "Chromosome Losses Mean Poor Survival In Childhood Leukemia." ScienceDaily. ScienceDaily, 13 May 2004. <www.sciencedaily.com/releases/2004/05/040512044332.htm>.
Ohio State University. (2004, May 13). Chromosome Losses Mean Poor Survival In Childhood Leukemia. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2004/05/040512044332.htm
Ohio State University. "Chromosome Losses Mean Poor Survival In Childhood Leukemia." ScienceDaily. www.sciencedaily.com/releases/2004/05/040512044332.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) — The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins