Featured Research

from universities, journals, and other organizations

Oxygen Therapy May Improve Vision Worsened By Diabetes

Date:
May 19, 2004
Source:
Johns Hopkins Medical Institutions
Summary:
Oxygen delivered through the nose may improve poor vision caused by diabetic macular edema, fluid buildup in the part of the eye responsible for central vision, according to a pilot study by scientists at Johns Hopkins and the National Eye Institute.

Oxygen delivered through the nose may improve poor vision caused by diabetic macular edema, fluid buildup in the part of the eye responsible for central vision, according to a pilot study by scientists at Johns Hopkins and the National Eye Institute.

Related Articles


In a study of five diabetic patients with persistent macular edema, breathing supplemental oxygen for three months reduced fluid buildup and swelling in the macula and, in some cases, improved visual acuity. Researchers think the therapy could be used in conjunction with laser treatments that also improve oxygenation in the retina to provide long-term stability in these patients.

"The results were really dramatic," says Peter A. Campochiaro, M.D., senior author of the study and a professor of ophthalmology and neuroscience at Hopkins' Wilmer Eye Institute. For the study, published in a recent issue of the journal Investigative Ophthalmology & Visual Science, the researchers studied nine eyes of three men and two women, ages 52 to 69, who had type 2 diabetes for an average of nine years. All patients had received at least one laser eye treatment. Despite an average of 2.7 treatments per eye, all eyes except one had persistent edema.

Patients were given 4 liters per minute of oxygen delivered by small tubes inserted into their noses, and instructed to use the oxygen continuously every day for three months, removing the tube only when taking showers. They were provided with a stationary oxygen concentrator for home and portable oxygen tanks to use outside the home.

After three months, excess thickness of the macula was reduced by an average of 43 percent in all nine eyes. Excess thickness of the fovea, the part of the eye responsible for the sharpest vision, was reduced by 42 percent, and macular volume dropped by 54 percent. In addition, three eyes improved in visual acuity, with the ability to see two lines higher on a standard eye chart.

"The likelihood that these measurements would change by such magnitudes by chance is very small," Campochiaro says.

Once the oxygen therapy was discontinued, vision slowly worsened in some eyes. But in four eyes in which retinal thickness had returned to the normal range while on oxygen, the improvement was maintained even after oxygen was stopped. Since these patients all had previous laser therapy, it is possible that the reduced thickening of the macula achieved by oxygen allowed the laser to exercise a stabilizing effect.

Diabetic macular edema affects up to 10 percent of all patients with diabetes. It is caused when high blood sugar, through a cascade of events, causes damage in normal retinal blood vessels and a decrease in the supply of oxygen and nutrients. Campochiaro and Quan Dong Nguyen, M.D., the principal investigator on the study, hypothesize that the retina, when faced with a decrease in oxygen, releases vascular endothelial growth factor (VEGF) and other substances that cause retinal blood vessels to become leaky and ultimately stimulate the growth of new blood vessels. The leakage of fluid into the macula causes it to become thickened and results in vision loss.

Supplemental oxygen reduces production of VEGF and similar proteins, which in turn reduces the amount of leaking in retinal vessels and lessens the severity of macular edema. The treatment could reduce the thickness of the retina before laser treatment, making the laser more effective and more likely to maintain stability without supplemental oxygen. Alternately, supplemental oxygen could be combined with newer treatments that directly target VEGF. For example, Campochiaro and colleagues also studied an oral drug that blocks receptors for VEGF, called PKC412, which was found to significantly reduce macular edema and improve visual acuity in diabetics. This first demonstration of directly targeting VEGF was reported by the researchers in another study published in the March issue of the journal.

"This confirms that VEGF is a good target for treatment of diabetic macular edema," Campochiaro says.

Several drugs that antagonize VEGF in different ways are now being tested in patients with diabetic macular edema.

The study was supported by the National Eye Institute. Coauthors were Quan Dong Nguyen, Syed Mahmood Shah, Elizabeth Van Anden and Jennifer U. Sung of Hopkins, and Susan Vitale of the National Eye Institute.

-JHMI-

Nguyen, Q.D. et al, "Supplemental Oxygen Improves Diabetic Macular Edema: A Pilot Study," Investigative Ophthalmology & Visual Science, February 2004, Vol. 45, No. 2, pages 617-624.

Campochiaro, P.A., and the C99-PKC412-03 Study Group, "Reduction of Diabetic Macular Edema by Oral Administration of the Kinase Inhibitor PKC412," Investigative Ophthalmology & Visual Science, March 2004, Vol. 45, No. 3, pages 922-931.

Links:

Johns Hopkins' Wilmer Eye Institutehttp://www.wilmer.jhu.edu

Investigative Ophthalmology & Visual Sciencehttp://www.iovs.org/

National Eye Institutehttp://www.nei.nih.gov


Story Source:

The above story is based on materials provided by Johns Hopkins Medical Institutions. Note: Materials may be edited for content and length.


Cite This Page:

Johns Hopkins Medical Institutions. "Oxygen Therapy May Improve Vision Worsened By Diabetes." ScienceDaily. ScienceDaily, 19 May 2004. <www.sciencedaily.com/releases/2004/05/040519071528.htm>.
Johns Hopkins Medical Institutions. (2004, May 19). Oxygen Therapy May Improve Vision Worsened By Diabetes. ScienceDaily. Retrieved March 28, 2015 from www.sciencedaily.com/releases/2004/05/040519071528.htm
Johns Hopkins Medical Institutions. "Oxygen Therapy May Improve Vision Worsened By Diabetes." ScienceDaily. www.sciencedaily.com/releases/2004/05/040519071528.htm (accessed March 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, March 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins