Featured Research

from universities, journals, and other organizations

Olfactory System Matures In Different Stages

Date:
June 16, 2004
Source:
Yale University
Summary:
Full development of the sense of smell in mammals is dependent on functional activity during critical periods in development, according to a study by researchers at Yale, Rockefeller and Columbia Universities and published in the journal Science.

New Haven, Conn. -- Full development of the sense of smell in mammals is dependent on functional activity during critical periods in development, according to a study by researchers at Yale, Rockefeller and Columbia Universities and published in the journal Science.

Related Articles


In mammals, the connection between odor and the brain occurs over a single nerve connection. The olfactory sensory neurons (OSNs) that have the same odorant receptor (OR) are directed to regions of the olfactory bulb, where they coalesce into a single structure, a glomerulus. This process is molecularly determined, but it remains controversial to what extent the process also relies on stimulation from the outside.

The visual system, it is known, develops initially without any functional activity, but is later refined and polished through sensory activity. Charles Greer, professor of neurosurgery at Yale, and his collaborators. examined the postnatal formation of glomeruli in odor receptors M71 and M72 in gene-targeted mice during development to determine whether the same development process is found in the olfactory system.

The results of the study established four principles of olfactory system development -- without sensory activity there is no full maturation; there is a sensitive period during which activity influences the maturation of the organization; sensitive periods occur at different times for different olfactory receptors; and glomeruli may be innervated by more than one kind of sensory nerve during early development.

###

The lead author on the paper was Dong-Jing Zou of Columbia. Co-authors included Paul Feinstein and Peter Mombaerts of Rockefeller University; Aimee Rivers, Glennis Matthews, Ann Kim and Stuart Feinstein, from Columbia.

Citation: Science, (Sciencexpress): pp 1-10 (June 3, 2004)


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Olfactory System Matures In Different Stages." ScienceDaily. ScienceDaily, 16 June 2004. <www.sciencedaily.com/releases/2004/06/040616062722.htm>.
Yale University. (2004, June 16). Olfactory System Matures In Different Stages. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2004/06/040616062722.htm
Yale University. "Olfactory System Matures In Different Stages." ScienceDaily. www.sciencedaily.com/releases/2004/06/040616062722.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com
Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Despite Rising Death Toll, Many Survive Ebola

Despite Rising Death Toll, Many Survive Ebola

AP (Oct. 23, 2014) The family of a Dallas nurse infected with Ebola in the US says doctors can no longer detect the virus in her. Despite the mounting death toll in West Africa, there are survivors there too. (Oct. 23) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins