Featured Research

from universities, journals, and other organizations

Drug Tested At OHSU Prevents MS-like Disease In Animals

Date:
June 21, 2004
Source:
Oregon Health & Science University
Summary:
Scientists from the Neurological Sciences Institute at Oregon Health & Science University have shown that an investigative drug for multiple sclerosis and related diseases prevented disease development when tested on animal models.

NEW ORLEANS, La. – Scientists from the Neurological Sciences Institute at Oregon Health & Science University have shown that an investigative drug for multiple sclerosis and related diseases prevented disease development when tested on animal models.

The drug, LGD5552, prevented rats from developing a well-established animal model of MS. San Diego-based Ligand Pharmaceuticals Inc. collaborated in, and funded, the study. The results are being presented today at Endo 2004, the national meeting of The Endocrine Society in New Orleans, La.

"While there is much more research to be done on this compound, these initial results are very exciting," explained Bruce Bebo Jr. Ph.D., a scientist at NSI and assistant professor of neurology in the OHSU School of Medicine. "LGD5552 is a member of a class of drugs called non-steroidal selective glucocorticoid receptor modulators with very effective, anti-inflammatory properties and a profile of tissue selectivity resulting in limited side-effects when compared to other drugs currently used to treat MS and related diseases."

Bebo and his collaborators studied rats suffering from experimental autoimmune encephalitis, a commonly studied animal model for human MS that has been used for about 50 years. The researchers provided some of the animals with LGD5552 at the time of disease induction. A second group of animals received a related anti-inflammatory called prednisolone. The third group of animals went untreated.

While the untreated animals developed paralysis , prednisolone-treated animals suffered reduced effects and LGD5552-treated animals remained free of weakness. In addition, the LGD5552-treated animals maintained their body weights, while other animals in the study lost weight. Animals that received the test drug also didn't develop inflammatory lesions in the spinal cord as did other animals. These lesions also are common in humans suffering from MS.

"One encouraging prospect of LGD5552 is that our data shows the compound will have reduced side effects," Bebo said. "Current medications available for MS and related disorders can cause high blood pressure, fat metabolism problems and osteoporosis. While additional research needs to be conducted on the orally administered test drug, we believe these commonly witnessed side effects will be reduced. "

"Glucocorticoids have been used to treat MS for decades. Unfortunately, they have lots of side-effects which limit how long you can use them," Said Dennis Bourdette, M.D., chairman of the OHSU Department of Neurology and Director of the MS Center of Oregon. "LGD5552 and related drugs open the possibility of treating MS patients long-term with a glucocorticoid-type drug without all the side-effects. This is a very exciting prospect."

"We are very excited about the data indicating that LGD5552, a non steroidal-glucocorticoid with tissue selective properties, prevents disease development in a model of multiple sclerosis," said Andres-Negro Vilar, M.D., Ph.D., Ligand's executive vice president research and development and chief scientific officer. "In the initial study, designed to assess the potential of the compound for the treatment of multiple sclerosis, LGD5552 showed efficacy equivalent to the current standard of therapy, the steroidal glucocorticoid prednisolone. In addition, our compound showed a more robust response to treatment, as no animals in study developed the disease. In contrast, 25 percent of animals in the prednisolone-treated group presented a blunted disease process in spite of treatment. Since LGD5552 exhibits an improved side effect profile as compared with steroidal glucocorticoids, this new family of compounds may provide novel avenues for more prolonged use of non-steroidal glucocorticoids for the treatment of multiple sclerosis."

Ligand discovers, develops and markets new drugs that address critical unmet medical needs of patients in the areas of cancer, pain, skin diseases, men's and women's hormone-related diseases, osteoporosis, metabolic disorders, and cardiovascular and inflammatory diseases. Ligand's proprietary drug discovery and development programs are based on its leadership position in gene transcription technology, primarily related to Intracellular Receptors (IRs) and Signal Transducers and Activators of Transcription (STATs). For more information, go to www.ligand.com.

Located on OHSU's West Campus, the Neurological Sciences Institute at OHSU studies nervous and sensory systems using a wide range of techniques from the level of molecules to the level of behaving human beings.

OHSU includes the schools of dentistry, medicine, nursing and science and engineering; OHSU Hospital and Doernbecher Children's Hospital; numerous primary care and specialty clinics; multiple research institutes; and several outreach and community service units.


Story Source:

The above story is based on materials provided by Oregon Health & Science University. Note: Materials may be edited for content and length.


Cite This Page:

Oregon Health & Science University. "Drug Tested At OHSU Prevents MS-like Disease In Animals." ScienceDaily. ScienceDaily, 21 June 2004. <www.sciencedaily.com/releases/2004/06/040621071344.htm>.
Oregon Health & Science University. (2004, June 21). Drug Tested At OHSU Prevents MS-like Disease In Animals. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2004/06/040621071344.htm
Oregon Health & Science University. "Drug Tested At OHSU Prevents MS-like Disease In Animals." ScienceDaily. www.sciencedaily.com/releases/2004/06/040621071344.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins