Featured Research

from universities, journals, and other organizations

Origins Of Blood Vessel Cells

Date:
July 2, 2004
Source:
Indiana University
Summary:
Researchers at the Indiana University School of Medicine have discovered how the body makes the cells that line its blood vessels, work that could someday lead to dramatic new treatments for vascular problems ranging from stroke to diabetes.

Indianapolis -- Researchers at the Indiana University School of Medicine have discovered how the body makes the cells that line its blood vessels, work that could someday lead to dramatic new treatments for vascular problems ranging from stroke to diabetes.

The origin of these endothelial cells, which play a vital role in the body's circulatory system and internal organs, has been uncertain. But by extracting and comparing cells from adult blood and infant umbilical cords, the IU team was able to isolate the parents -- the progenitors -- of the cells and explain how they differ from related cells.

The progenitor cells that the researchers identified are adult type stem cells, but they proliferate much like embryonic stem cells, and they can be grown in large quantities in the laboratory, said Mervin C. Yoder, M.D., Richard and Pauline Klingler professor of pediatrics and of biochemistry and molecular biology.

The research appears in the online version of Blood, the journal of the American Society of Hematology.

Endothelial cells make up the inner lining of the blood vessels in the body, as well as the capillary beds where the blood delivers its nutrients and oxygen to other cells.

The researchers found that the endothelial cells are formed in a manner similar to the blood cells carried by the circulatory system, said David A. Ingram, Jr., M.D., assistant professor of pediatrics.

The red blood cells that carry oxygen and "white" cells that make up the body's immune system are descended from a series of progressively less differentiated cells, created in a process called hematopoiesis ("hee-matt-oh-po-esis"). The source of those less differentiated cells are a relative handful of hematopoietic stem cells, found mainly in the bone marrow. Researchers have been attempting to use hematopoietic stem cells in gene therapy, hoping to correct immune disorders, certain cancers and other genetic problems by inserting genes into the stem cells. Progress has been slow, however, because hematopoietic stem cells are hard to find, difficult to grow in the laboratory and hard to modify with genes.

The endothelial progenitor cells, on the other hand, not only grew exceedingly well, but were easily modified with new genes, raising the prospects of a new gene therapy tool, Yoder said. He foresees a day -- many years in the future -- when genetically modified endothelial stems cells would help diabetes patients reverse the circulatory problems that threaten them with the loss of extremities from amputation. Or the day could come in which modified cells would be injected to quickly begin a process of blood vessel repair after a heart attack.

Previously, researchers have attempted to identify possible endothelial progenitor cells using indirect measures involving certain protein "markers" on the surfaces of cells. The Indiana University scientists, however, were able to isolate the endothelial progenitor cells directly from cord blood and grow them the laboratory. Unlike the cells previously identified in adult blood as possible endothelial progenitor cells, the cord blood progenitor cells could be grown for at least 100 new generations, forming many new colonies of cells.


Story Source:

The above story is based on materials provided by Indiana University. Note: Materials may be edited for content and length.


Cite This Page:

Indiana University. "Origins Of Blood Vessel Cells." ScienceDaily. ScienceDaily, 2 July 2004. <www.sciencedaily.com/releases/2004/07/040702090922.htm>.
Indiana University. (2004, July 2). Origins Of Blood Vessel Cells. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2004/07/040702090922.htm
Indiana University. "Origins Of Blood Vessel Cells." ScienceDaily. www.sciencedaily.com/releases/2004/07/040702090922.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins