Featured Research

from universities, journals, and other organizations

Penn Researchers Offer New Hope To Advanced Stage Lung Cancer Patients

Date:
August 5, 2004
Source:
University Of Pennsylvania Medical Center
Summary:
A new study that appears in the June 2004 issue of the Journal of Clinical Oncology shows that the life-expectancy of patients with advanced stage lung cancer can be extended with the use of photodynamic therapy, or PDT, in addition to surgical intervention.

Philadelphia, PA -- A new study that appears in the June 2004 issue of the Journal of Clinical Oncology shows that the life-expectancy of patients with advanced stage lung cancer can be extended with the use of photodynamic therapy, or PDT, in addition to surgical intervention. Typically, advanced stage non-small cell lung cancer patients have a median survival of 6-9 months when treated with the current standard of care, chemotherapy alone. However, this same set of patients demonstrated a median survival of more than 22 months when chemotherapy was combined with surgery and intraoperative PDT, a new laser-based cancer treatment. Joseph S. Friedberg, MD, Chief of Thoracic Surgery at Presbyterian-University of Pennsylvania Medical Center, Stephen Hahn, MD, Clinical Associate Professor of Radiation Therapy and James P. Stevenson, MD, Assistant Professor of Medicine are the co-investigators in this trial at the University of Pennsylvania Medical Center.

Related Articles


“We consider these results preliminary but extremely encouraging. We expected PDT to make a difference in the rate of local recurrence and it has,” says Dr. Friedberg, “However, we did not anticipate the dramatic increase in survival that we have observed. In addition to the local control, there must be some sort of systemic immune response that is contributing to the enhanced survival we are observing in these patients with a very advanced form of the disease. We are exploring this phenomenon at a number of levels and feel we may have stumbled upon the makings of a new immunologic approach to treating patients with all stages of lung cancer. It is an area of research about which we are very excited and actively pursuing.”

In PDT, a nontoxic photosensitizing agent, Photofrin, is injected into the blood stream and concentrates in cancer cells, allowing the cancer to become very sensitive to light. Using a laser to shine light on these cells results in a very effective mechanism for killing cancer cells. The damage occurs only where the light is shined, limiting the harm to healthy tissue. PDT has rarely been used in this way, combining it with other treatment modalities, although it has been used by clinicians for treating small, easily visualized tumors in the windpipe and esophagus. Patients eligible for the treatment are those whose cancer has spread within the chest cavity.

In the study, each patient is treated with chemotherapy until the cancer stops responding, the normal course for this disease and the limitation of chemotherapy alone. After it is confirmed that the cancer has not spread beyond the chest cavity, the patient then receives Photofrin 24 hours prior to surgery. During surgery, the cancer is removed, which may involve excising all or part of the affected lung. Then, surgeons shine a laser into the chest cavity, giving the appropriate dose of light in an effort to kill any remaining microscopic tumor cells that remain after surgery.

It is known that surgery, without PDT, will almost certainly be accompanied by a high rate of local recurrence, likely a result of the invisible remaining disease being targeted with PDT. The treatment has proven very safe, largely as a function of using a specially designed computer system to measure and monitor the amount of laser light delivered at the time of treatment.


Story Source:

The above story is based on materials provided by University Of Pennsylvania Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University Of Pennsylvania Medical Center. "Penn Researchers Offer New Hope To Advanced Stage Lung Cancer Patients." ScienceDaily. ScienceDaily, 5 August 2004. <www.sciencedaily.com/releases/2004/08/040805091402.htm>.
University Of Pennsylvania Medical Center. (2004, August 5). Penn Researchers Offer New Hope To Advanced Stage Lung Cancer Patients. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2004/08/040805091402.htm
University Of Pennsylvania Medical Center. "Penn Researchers Offer New Hope To Advanced Stage Lung Cancer Patients." ScienceDaily. www.sciencedaily.com/releases/2004/08/040805091402.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins