Featured Research

from universities, journals, and other organizations

New Technique For Thyroid Cancer Therapy Eliminates Many Side Effects

Date:
September 20, 2004
Source:
Society Of Nuclear Medicine
Summary:
A new technique allows patients to maintain their normal course of thyroid medication prior to and during radioiodine therapy. The technique avoids the problems of hypothyroidism, and levels of radiation in the blood and bone marrow remain well below the accepted safety thresholds during therapy.

Reston, VA -- Differentiated thyroid cancer, the most common form of thyroid cancer, is one of the success stories in the war on cancer. Since the advent of radioiodine therapy, it has been considered one of the most curable cancers. On the downside, current treatment involves taking patients off their thyroid medication. This can lead to serious side effects including symptoms of hypothyroidism, an unbalanced metabolic state that can induce fatigue, depression, and other unpleasant conditions.

Bart de Keizer, MD, and a team from the University Medical Center in Utrecht, The Netherlands, and Ghent University Hospital, Belgium, reported in the September issue of The Journal of Nuclear Medicine, on a new technique that allows patients to maintain their normal course of thyroid medication prior to and during radioiodine therapy. The new technique avoids the problems of hypothyroidism, and levels of radiation in the blood and bone marrow remain well below the accepted safety thresholds during therapy.

Currently, thyroid cancer patients who have had their thyroid removed are treated with radioactive iodine, which effectively zeros in on and kills any remaining cancerous thyroid cells. But prior to radioiodine treatment, the patient must be taken off thyroid hormone replacement medication for up to 6 weeks. The withdrawal of thyroid medication signals the body to produce thyroid stimulating hormone (THS). TSH causes any remaining or metastasized thyroid cells to quickly absorb the radioactive iodine when it is administered, in effect forcing the cancerous cells to absorb lethal radioactive molecules that are largely ignored by other cells in the body.

By using a genetically engineered version of the natural hormone (recombinant human thyroid stimulating hormone [rhTSH]) instead of thyroid medication withdrawal to stimulate the cancerous cells to quickly take up the radioactive iodine, the research team in The Netherlands and Belgium found that the problems of hypothyroidism can be avoided. This new technique may also increase the safety of radioiodine treatment and may allow a higher, more effective dose of radioiodine to be used when needed. That's because when the body is not in a state of hypothyroidism, it can more efficiently process and excrete any radioiodine that hasn't been absorbed.

The study, which involved 14 patients and 17 treatments, showed that treatment with rhTSH was well tolerated. None of the patients showed blood toxicity, and no bone marrow-related side effects were noted. Blood and bone marrow are the tissues most sensitive to radiation. As expected, none of the patients showed symptoms of hypothyroidism during or following treatment.

According to Dr. de Keizer, "Using rhTSH before administering radioiodine treatments resulted in no clinically relevant side effects. Therefore, although further testing needs to be done, our findings imply this treatment should improve efficacy while preserving safety and tolerability of treatment."

###

"Bone marrow dosimetry and safety of high I-131 activities given after recombinant human thyrotropin-stimulating hormone to treat metastatic differentiated thyroid cancer" was written by Bart de Keizer, MD, Anne Hoekstra, MsC, Peter P. van Rijk, MD, PhD, and John M.H. de Klerk MD, PhD, from the Department of Nuclear Medicine, Utrecht, The Netherlands; Mark W. Konijnenberg, MsC, from Research and Development, Mallinckrodt, Tyco Healthcare, Petten, The Netherlands; Filip de Vos, MsC, and Bieke Lambert, MsC, from the Department of Nuclear Medicine, Ghent University Hospital, Belgium; and Cees J.M. Lips, MD, PhD from the Department of Endocrinology, Utrecht University Hospital, Utrecht, The Netherlands.


Story Source:

The above story is based on materials provided by Society Of Nuclear Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Society Of Nuclear Medicine. "New Technique For Thyroid Cancer Therapy Eliminates Many Side Effects." ScienceDaily. ScienceDaily, 20 September 2004. <www.sciencedaily.com/releases/2004/09/040920063817.htm>.
Society Of Nuclear Medicine. (2004, September 20). New Technique For Thyroid Cancer Therapy Eliminates Many Side Effects. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2004/09/040920063817.htm
Society Of Nuclear Medicine. "New Technique For Thyroid Cancer Therapy Eliminates Many Side Effects." ScienceDaily. www.sciencedaily.com/releases/2004/09/040920063817.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

EU Ministers and Experts Meet to Discuss Ebola Reponse

EU Ministers and Experts Meet to Discuss Ebola Reponse

AFP (Sep. 15, 2014) The European Commission met on Monday to coordinate aid that the EU can offer to African countries affected by the Ebola outbreak. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
Despite The Risks, Antibiotics Still Overprescribed For Kids

Despite The Risks, Antibiotics Still Overprescribed For Kids

Newsy (Sep. 15, 2014) A new study finds children are prescribed antibiotics twice as often as is necessary. Video provided by Newsy
Powered by NewsLook.com
FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com
Respiratory Virus Spreads To Northeast, Now In 21 States

Respiratory Virus Spreads To Northeast, Now In 21 States

Newsy (Sep. 14, 2014) The respiratory virus Enterovirus D68, which targets children, has spread from the Midwest to 21 states. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins