Featured Research

from universities, journals, and other organizations

Dartmouth Study Suggests Caution Against Using Certain Drugs To Unclog Heart Arteries

Date:
October 14, 2004
Source:
Dartmouth Medical School
Summary:
Dartmouth Medical School cardiology researchers have discovered a new mechanism for what drives the growth of muscle tissue in the lining of injured heart vessels that can eventually lead to blockage. Their study, reported in the October 19 issue of the journal Circulation, raises important questions about the use of drugs that promote or prevent angiogenesis - the formation of blood vessels - to treat the condition.

HANOVER, NH – Dartmouth Medical School cardiology researchers have discovered a new mechanism for what drives the growth of muscle tissue in the lining of injured heart vessels that can eventually lead to blockage. Their study, reported in the October 19 issue of the journal Circulation, raises important questions about the use of drugs that promote or prevent angiogenesis - the formation of blood vessels - to treat the condition.

Normal heart arteries have a muscle tissue layer inside their walls. In coronary artery disease or in response to mechanical injury such as angioplasty (a non-surgical procedure to open clogged arteries), new smooth muscle cells grow along the innermost layer of the arterial lining and leads to narrowing. Such muscle buildup also occurs with use of a stent – a small wire mesh tube inserted after angioplasty to keep the artery clear.

It is the most common cause of stent failure, according to Michael Simons, professor of medicine and of pharmacology and toxicology at Dartmouth Medical School and chief of cardiology at Dartmouth-Hitchcock Medical Center, who headed the research team. Based on the research, Simons cautions against using angiogenic drugs to unblock arteries in certain heart conditions. He indicated that stents coated with agents that specifically target smooth muscle to prevent or kill growth should remain the treatment of choice at present. "They are not perfect, so everyone is looking for what can be added to make things better," he noted.

The biological drivers of the smooth muscle accumulation are unclear. Injury may somehow alter the tissue on the inner arterial layer, called the intima, so it is susceptible to factors in the blood that induce smooth muscle cells to proliferate. At the same time, there is an intense inflammatory response on the outermost layer of the arterial wall that also appears to be involved in stimulating blood vessels to feed smooth muscle accumulation.

Recent studies of the angiogenesis process have provided new insights into understanding cardiovascular disorders. Regulating angiogenesis with agents that promote or prevent blood vessel growth is considered a promising approach for treating a number of diseases. The researchers found that injured arteries grow smooth muscle in two distinct ways: one that depends on angiogenesis and another that is independent. "So even if no there is no angiogenesis, mechanical injury alone will still stimulate smooth muscle growth," Simons said.

This duality could make both angiogenesis-promoting and angiogenesis-suppressing drugs ineffective in preventing renarrowing of arteries following angioplasty or stenting. "In fact, pro-angiogenic drugs could make things worse, not better," Simons said. "If you're going to use an angiogenic agent, it will do harm, because it will actually promote stenosis [narrowing] instead of inhibiting it."

The studies were done in rabbits, chosen for their thick human-like arteries. Using an agent to stimulate angiogenesis on the outer surface after local injury, the researchers found a large increase in smooth muscle in the inside lining of the artery, meaning that angiogenesis induced intimal growth that narrowed the blood vessel. Then, using different agents to inhibit angiogenesis, they showed that even when angiogenesis was completely stopped, some new muscle accumulated.

"Intimal growth is a fundamental pathology responsible for many cardiovascular diseases including atherosclerosis and hypertension," Simons said. "This is the first time such a combination of angiogenesis-dependent and independent phases of smooth muscle growth has been proposed."

Study co-authors are Dr. Rohit Khurana, who was a visiting Fulbright scholar from University College London, Dr. Zhenwu Zhuang, Dr. Masahiro Murakami, and Dr. Ebo De Muinck, all from Dartmouth Medical School, as well as colleagues from London, Finland and Genentech of San Francisco.


Story Source:

The above story is based on materials provided by Dartmouth Medical School. Note: Materials may be edited for content and length.


Cite This Page:

Dartmouth Medical School. "Dartmouth Study Suggests Caution Against Using Certain Drugs To Unclog Heart Arteries." ScienceDaily. ScienceDaily, 14 October 2004. <www.sciencedaily.com/releases/2004/10/041012084035.htm>.
Dartmouth Medical School. (2004, October 14). Dartmouth Study Suggests Caution Against Using Certain Drugs To Unclog Heart Arteries. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2004/10/041012084035.htm
Dartmouth Medical School. "Dartmouth Study Suggests Caution Against Using Certain Drugs To Unclog Heart Arteries." ScienceDaily. www.sciencedaily.com/releases/2004/10/041012084035.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins