Featured Research

from universities, journals, and other organizations

Olfactory Bulb Stem Cells And Lou Gehrig's Disease

Date:
October 27, 2004
Source:
Johns Hopkins Medical Institutions
Summary:
Johns Hopkins researchers have found that transplants of mouse stem cells taken from the adult brain's olfactory bulb can delay symptoms and death in a mouse model of amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease.

Johns Hopkins researchers have found that transplants of mouse stem cells taken from the adult brain's olfactory bulb can delay symptoms and death in a mouse model of amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease. They are scheduled to present their findings Oct. 24 at the annual meeting of the Society for Neuroscience in San Diego.

Related Articles


The olfactory bulb, the center of smell detection, houses numerous primitive stem cells that normally feed the constant, life-long regeneration of odor-detecting nerves. Because they are found in a fairly accessible region of the brain and could conceivably be removed from a person's olfactory bulb without causing permanent damage, adult olfactory bulb stem cells are a potential non-embryonic source for cells that could prove useful in replacing nerve cells lost due to injury or diseases like ALS and Parkinson's.

Researchers Zhiping Liu, Ph.D., and Lee Martin, Ph.D., who have carefully characterized cells from the olfactory bulb in people, rats and mice, grew clusters of neuronal stem cells taken from the olfactory bulb of normal mice and froze them. Retrieved cells were then transplanted into the spinal cords of genetically engineered mice that develop the equivalent of ALS.

Animals that got the transplanted cells did develop disease symptoms, but did so about a month and a half later than non-transplanted animals (137 days versus 90 days of age, on average). Treated mice also lived about two months longer than untreated mice, who were euthanized at roughly 137 days because of their disease.

"These transplants significantly prolonged the animals' lives by becoming neurons and probably also by influencing existing nerve cells," says Martin, an associate professor of pathology and neuroscience at Johns Hopkins. "The transplants definitely provided a functional improvement, and we're hopeful about the potential of these adult neuronal stem cells in treating ALS some day. But there is a great deal of laboratory work to do before clinical trials would be appropriate."

The research was funded by the ALS Association.


Story Source:

The above story is based on materials provided by Johns Hopkins Medical Institutions. Note: Materials may be edited for content and length.


Cite This Page:

Johns Hopkins Medical Institutions. "Olfactory Bulb Stem Cells And Lou Gehrig's Disease." ScienceDaily. ScienceDaily, 27 October 2004. <www.sciencedaily.com/releases/2004/10/041025121323.htm>.
Johns Hopkins Medical Institutions. (2004, October 27). Olfactory Bulb Stem Cells And Lou Gehrig's Disease. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2004/10/041025121323.htm
Johns Hopkins Medical Institutions. "Olfactory Bulb Stem Cells And Lou Gehrig's Disease." ScienceDaily. www.sciencedaily.com/releases/2004/10/041025121323.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins