Featured Research

from universities, journals, and other organizations

Malaria Vaccine Trial Results Published

Date:
November 1, 2004
Source:
Public Library Of Science
Summary:
The results of a randomized controlled trial of a malaria vaccine called ME-TRAP are published this month in PLoS Medicine. "This first field efficacy trial was an important milestone in the progression of new recombinant vectored vaccines to deployable products," says Adrian Hill (University of Oxford, United Kingdom), the senior investigator of the study.

The results of a randomized controlled trial of a malaria vaccine called ME-TRAP are published this month in PLoS Medicine. "This first field efficacy trial was an important milestone in the progression of new recombinant vectored vaccines to deployable products," says Adrian Hill (University of Oxford, United Kingdom), the senior investigator of the study. "The safety profile was excellent and the efficacy data provide a first indication of the levels of cellular immunogenicity that will be required for preventing infection," he says.

The researchers recruited volunteers from 13 Gambian villages that were close to the alluvial flood plain and so were at high risk of developing malaria. They randomly assigned the 372 volunteers to receive either two doses of the malaria vaccine or three doses of rabies vaccine, which acted as a control. This three-dose schedule is similar to the one used by the World Health Organization/United Nations Children's Fund Expanded Program on Immunization.

The time to first infection was similar in the two groups, with an estimated vaccine efficacy of only 10%. However, the immune response, measured one week after the third vaccination, was 80 times higher in the DNA/MVA vaccine group than in the rabies vaccine group.

"It is absolutely crucial that results like these are published, since the failures, as well as the successes, need to be documented if we are to move towards rational strategies for optimizing malaria vaccines," says Tom Smith from the Swiss Tropical Institute, who was not involved in the study. "At the same time, it makes sense to move on quickly without shedding too many tears, in a field that is moving much faster than it was before the recent injections of money from the Gates Foundation, but where it is still impossible to second-guess the results of field trials. This is partly because we do not have any good proxy measures of effective immunity in P. falciparum, and partly because this is a fertile area for trying out new techniques, such as DNA vaccines, where there is still a lot to learn."

Hill is planning to do further trials that address the important question of whether this type of vaccine can prevent the symptoms of malaria. "The next step," says Hill, "is to assess newer vaccine regimes that employ two viral vectors rather than DNA and to study prevention of malaria rather than infection."

###

Citation: Moorthy VS, Imoukhuede EB, Milligan P, Bojang K, Keating S, et al (2004) A randomised, controlled, double-blind efficacy trial of DNA/MVA ME-TRAP prime-boost immunisation against malaria infection in Gambian adults. PLoS Med 1 (2): e33.


Story Source:

The above story is based on materials provided by Public Library Of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library Of Science. "Malaria Vaccine Trial Results Published." ScienceDaily. ScienceDaily, 1 November 2004. <www.sciencedaily.com/releases/2004/10/041030153127.htm>.
Public Library Of Science. (2004, November 1). Malaria Vaccine Trial Results Published. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2004/10/041030153127.htm
Public Library Of Science. "Malaria Vaccine Trial Results Published." ScienceDaily. www.sciencedaily.com/releases/2004/10/041030153127.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins