Featured Research

from universities, journals, and other organizations

University Of Kentucky Researcher Uncovers Clues To Alzheimer's Disease

Date:
November 11, 2004
Source:
Case Western Reserve University
Summary:
University of Kentucky chemistry professor Allan Butterfield has uncovered new clues about how brain cells are damaged by Alzheimer's disease, evidence suggesting vitamin E may help prevent the debilitating illness.

University of Kentucky chemistry professor Allan Butterfield has uncovered new clues about how brain cells are damaged by Alzheimer's disease, evidence suggesting vitamin E may help prevent the debilitating illness.

In Butterfield's study, which was funded by the National Institutes of Health, he focused on amyloid beta peptide, a compound known to contribute to the senile plaques seen in the brains of Alzheimer's patients. The study compared amyloid beta peptide in an animal model to the same compound in humans and found both forms of the compound cause loss of connections between neurons and decreased cell viability as well as other damage associated with Alzheimer's.

Butterfield's study identified methionine in the human amyloid beta peptide as a key contributor to Alzheimer's disease. A previous theory held that it was the copper binding sites in the human peptide that contributed to Alzheimer's. His study found the animal form of the peptide, which does not have the copper binding sites, still causes damage. Butterfield says this indicates the damage to neurons caused by the human peptide in an Alzheimer's disease patient is related to the peptide's methionine residue.

Butterfield also demonstrated that in the animal form of the peptide, the introduction of the antioxidant vitamin E slowed the destruction of brain cells as it appears to in the human form. These results provide new insights into the mechanisms of action of human amyloid beta peptide, which many researchers believe causes the damage seen in the brains of Alzheimer's disease patients.

Butterfield's complete paper is in the October issue of the Journal of Alzheimer's Disease.


Story Source:

The above story is based on materials provided by Case Western Reserve University. Note: Materials may be edited for content and length.


Cite This Page:

Case Western Reserve University. "University Of Kentucky Researcher Uncovers Clues To Alzheimer's Disease." ScienceDaily. ScienceDaily, 11 November 2004. <www.sciencedaily.com/releases/2004/11/041104005015.htm>.
Case Western Reserve University. (2004, November 11). University Of Kentucky Researcher Uncovers Clues To Alzheimer's Disease. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2004/11/041104005015.htm
Case Western Reserve University. "University Of Kentucky Researcher Uncovers Clues To Alzheimer's Disease." ScienceDaily. www.sciencedaily.com/releases/2004/11/041104005015.htm (accessed April 24, 2014).

Share This



More Mind & Brain News

Thursday, April 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com
Do We Get Nicer With Age?

Do We Get Nicer With Age?

Newsy (Apr. 22, 2014) A recent report claims personality can change over time as we age, and usually that means becoming nicer and more emotionally stable. Video provided by Newsy
Powered by NewsLook.com
How to Master Motherhood With the Best Work/Life Balance

How to Master Motherhood With the Best Work/Life Balance

TheStreet (Apr. 22, 2014) In the U.S., there are more than 11 million couples trying to conceive at any given time. From helping celebrity moms like Bethanny Frankel to ordinary soon-to-be-moms, TV personality and parenting expert, Rosie Pope, gives you the inside scoop on mastering motherhood. London-born entrepreneur Pope is the creative force behind Rosie Pope Maternity and MomPrep. She explains why being an entrepreneur offers the best life balance for her and tips for all types of moms. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins