Featured Research

from universities, journals, and other organizations

University Of Kentucky Researcher Uncovers Clues To Alzheimer's Disease

Date:
November 11, 2004
Source:
Case Western Reserve University
Summary:
University of Kentucky chemistry professor Allan Butterfield has uncovered new clues about how brain cells are damaged by Alzheimer's disease, evidence suggesting vitamin E may help prevent the debilitating illness.

University of Kentucky chemistry professor Allan Butterfield has uncovered new clues about how brain cells are damaged by Alzheimer's disease, evidence suggesting vitamin E may help prevent the debilitating illness.

In Butterfield's study, which was funded by the National Institutes of Health, he focused on amyloid beta peptide, a compound known to contribute to the senile plaques seen in the brains of Alzheimer's patients. The study compared amyloid beta peptide in an animal model to the same compound in humans and found both forms of the compound cause loss of connections between neurons and decreased cell viability as well as other damage associated with Alzheimer's.

Butterfield's study identified methionine in the human amyloid beta peptide as a key contributor to Alzheimer's disease. A previous theory held that it was the copper binding sites in the human peptide that contributed to Alzheimer's. His study found the animal form of the peptide, which does not have the copper binding sites, still causes damage. Butterfield says this indicates the damage to neurons caused by the human peptide in an Alzheimer's disease patient is related to the peptide's methionine residue.

Butterfield also demonstrated that in the animal form of the peptide, the introduction of the antioxidant vitamin E slowed the destruction of brain cells as it appears to in the human form. These results provide new insights into the mechanisms of action of human amyloid beta peptide, which many researchers believe causes the damage seen in the brains of Alzheimer's disease patients.

Butterfield's complete paper is in the October issue of the Journal of Alzheimer's Disease.


Story Source:

The above story is based on materials provided by Case Western Reserve University. Note: Materials may be edited for content and length.


Cite This Page:

Case Western Reserve University. "University Of Kentucky Researcher Uncovers Clues To Alzheimer's Disease." ScienceDaily. ScienceDaily, 11 November 2004. <www.sciencedaily.com/releases/2004/11/041104005015.htm>.
Case Western Reserve University. (2004, November 11). University Of Kentucky Researcher Uncovers Clues To Alzheimer's Disease. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2004/11/041104005015.htm
Case Western Reserve University. "University Of Kentucky Researcher Uncovers Clues To Alzheimer's Disease." ScienceDaily. www.sciencedaily.com/releases/2004/11/041104005015.htm (accessed October 21, 2014).

Share This



More Mind & Brain News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
Portable Breathalyzer Gets You Home Safely

Portable Breathalyzer Gets You Home Safely

Buzz60 (Oct. 21, 2014) Breeze, a portable breathalyzer, gets you home safely by instantly showing your blood alcohol content, and with one tap, lets you call an Uber, a cab or a friend from your contact list to pick you up. Sean Dowling (@SeanDowlingTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Your Birth Season Might Determine Your Temperament

Your Birth Season Might Determine Your Temperament

Newsy (Oct. 20, 2014) A new study says the season you're born in can determine your temperament — and one season has a surprising outcome. Video provided by Newsy
Powered by NewsLook.com
Movies Might Desensitize Violence For Parents, Not Just Kids

Movies Might Desensitize Violence For Parents, Not Just Kids

Newsy (Oct. 20, 2014) A study suggests that parents become desensitized to violent movies as well as children, which leads them to allow their kids to view violent films. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins