Featured Research

from universities, journals, and other organizations

Protein Plays Different Roles In Growth Of Normal And Cancerous Mouse Cell Lines

Date:
November 22, 2004
Source:
NIH/National Cancer Institute
Summary:
Researchers at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), have found that inhibition of the same protein produces different effects in mouse cell lines depending on whether those cell lines expressing normal or cancerous forms of Kit, a cell surface receptor.

Researchers at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), have found that inhibition of the same protein produces different effects in mouse cell lines depending on whether those cell lines expressing normal or cancerous forms of Kit, a cell surface receptor. These findings, appearing in the journal Blood online on November 12, reveal a potential new target for treating certain blood cell disorders.

Related Articles


Kit is critical for the development of certain blood cells, and mutations in Kit are associated with several diseases in mast cells, a type of white blood cell involved in immune responses. Gleevec, a drug that inhibits Kit and other related proteins, has been useful in the treatment of diseases associated with these proteins, including gastrointestinal stromal cell tumors and chronic myeloid leukemia. However, an activating mutation in Kit commonly found in mast cell disease and some forms of acute myeloid leukemia is resistant to Gleevec. Therefore, one potential method of circumventing a drug-resistant form of Kit would be to target one or more of the proteins activated by it.

NCI researchers Diana Linnekin, Ph.D., and Tanya Jelacic, Ph.D., found that inhibition of one such Kit activated protein, PKC&#948; <PKCdelta> (a member of a family of protein kinases involved in cell signaling), reduced the growth of a mouse mast cell line expressing mutant Kit by approximately 40 percent, while the growth of normal mast cells was not inhibited. "This is the first demonstration of a function change in PKC&#948; <PKCdelta> resulting from an oncogenic mutation in a growth factor receptor," said Linnekin.

These results suggest that PKC&#948; <PKCdelta> may be a therapeutic target for diseases associated with mutations in Kit, since anti-PKC&#948; <PKCdelta> drugs would specifically inhibit the growth of mutated cells and not affect normal ones. "This work is a promising study on cancer inhibition," said Linnekin. "Dr. Jelacic and I believe that follow-up work with human cell lines, as well as work in mouse models of cancer, would be definitely worthwhile."

For more information about cancer, visit the NCI Web site at http://www.cancer.gov or call NCI's Cancer Information Service at 1-800-4-CANCER (1-800-422-6237).


Story Source:

The above story is based on materials provided by NIH/National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

NIH/National Cancer Institute. "Protein Plays Different Roles In Growth Of Normal And Cancerous Mouse Cell Lines." ScienceDaily. ScienceDaily, 22 November 2004. <www.sciencedaily.com/releases/2004/11/041118112702.htm>.
NIH/National Cancer Institute. (2004, November 22). Protein Plays Different Roles In Growth Of Normal And Cancerous Mouse Cell Lines. ScienceDaily. Retrieved October 26, 2014 from www.sciencedaily.com/releases/2004/11/041118112702.htm
NIH/National Cancer Institute. "Protein Plays Different Roles In Growth Of Normal And Cancerous Mouse Cell Lines." ScienceDaily. www.sciencedaily.com/releases/2004/11/041118112702.htm (accessed October 26, 2014).

Share This



More Health & Medicine News

Sunday, October 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
Toxin-Packed Stem Cells Used To Kill Cancer

Toxin-Packed Stem Cells Used To Kill Cancer

Newsy (Oct. 25, 2014) — A Harvard University Research Team created genetically engineered stem cells that are able to kill cancer cells, while leaving other cells unharmed. Video provided by Newsy
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins