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Technion Researchers Succeed In Building Cartilage Tissue Outside The Human Body

Date:
November 19, 2004
Source:
Technion - Israel Institute Of Technology
Summary:
Technion researchers have succeeded in building cartilage tissue outside of the human body. The researchers – Prof. Joseph Mizrahi and Dr. Dror Seliktar – built an innovative bioreactor, which creates mechanical stimulation that builds the tissue.

The bioreactor innovation which was built in the Technion.
Credit: Photo courtesy of Technion - Israel Institute Of Technology

Technion researchers have succeeded in building cartilage tissue outside of the human body. The researchers – Prof. Joseph Mizrahi and Dr. Dror Seliktar – built an innovative bioreactor, which creates mechanical stimulation that builds the tissue.

“The basis a polymer that serves as a scaffold within which we implant the cells,” explains Prof. Mizrahi, chairman of the Technion’s Biomedical Engineering Department. “The polymer solidifies thus enabling transfer of mechanical loads to the cells, which then begin to create protein. Eventually, this protein replaces the polymer scaffold which wears away.”

Dr. Seliktar adds that the “scaffold” is engineered to degrade away during the dynamics of the protein production. “The scaffold becomes superfluous when the protein is created,” he explains.

The research was carried out in cooperation with Dr. Jennifer Elisseeff from The Johns Hopkins University in the Baltimore, MD, who succeeded in growing fetal stem cells in goat tissue in a way that simulates bone cell development. “We want to direct the basic, primitive cell to develop into a cartilage cell or a bone cell,” explains Prof. Mizrahi. “We are researching if existing environmental conditions cause the cell to become a cartilage or bone cell.”

The Technion researchers clarify that the regenerative ability of cartilage tissue in cases of damage or wear is very limited and nearly non-existent in adults. Therefore, many people suffer from back or joint pains.


Story Source:

The above story is based on materials provided by Technion - Israel Institute Of Technology. Note: Materials may be edited for content and length.


Cite This Page:

Technion - Israel Institute Of Technology. "Technion Researchers Succeed In Building Cartilage Tissue Outside The Human Body." ScienceDaily. ScienceDaily, 19 November 2004. <www.sciencedaily.com/releases/2004/11/041119013834.htm>.
Technion - Israel Institute Of Technology. (2004, November 19). Technion Researchers Succeed In Building Cartilage Tissue Outside The Human Body. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2004/11/041119013834.htm
Technion - Israel Institute Of Technology. "Technion Researchers Succeed In Building Cartilage Tissue Outside The Human Body." ScienceDaily. www.sciencedaily.com/releases/2004/11/041119013834.htm (accessed April 24, 2014).

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