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UCLA Brain Researchers Uncover New Clues To SIDS

Date:
November 23, 2004
Source:
University Of California - Los Angeles
Summary:
Two new UCLA studies have identified brain irregularities in children who suffer from congenital central hypoventilation syndrome (CCHS), a disease in which children stop breathing during sleep, often resulting in their suffocation and death.

Two new UCLA studies have identified brain irregularities in children who suffer from congenital central hypoventilation syndrome (CCHS), a disease in which children stop breathing during sleep, often resulting in their suffocation and death. The scientists tested how CCHS children's brains react to carbon dioxide and low oxygen levels in comparison to the brains of healthy children.

Several unexpected regions in the healthy children's brains responded to the gases – particularly in sites that perceive and react to the sensation of breathlessness during suffocation. The same regions in CCHS children's brains responded poorly or not at all. This may explain why the children do not struggle to breathe when their lungs shut down -- even after turning blue from lack of air.

The findings suggest that the irregular brain mechanisms provoking CCHS may also underlie sudden infant death syndrome (SIDS). Children afflicted by the two conditions share many of the same symptoms and health problems.

Authors of the study are Ronald Harper, Ph.D., professor of neurobiology, and Paul Macey, Ph.D., neurobiology postdoctoral researcher, at the David Geffen School of Medicine at UCLA.

Their findings appear in Journal of Neurophysiology, Nov. 3, 2004, "Hypoventilation reveals central nervous system respiratory control mechanisms" http://jn.physiology.org/papbyrecent.shtmlJournal of Applied Physiology, Nov. 5, 2004, "Hypoxia reveals posterior thalamic, cerebellar, midbrain and limbic deficits in congenital central hypoventilation syndrome" http://jap.physiology.org/papbyrecent.shtml


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The above story is based on materials provided by University Of California - Los Angeles. Note: Materials may be edited for content and length.


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University Of California - Los Angeles. "UCLA Brain Researchers Uncover New Clues To SIDS." ScienceDaily. ScienceDaily, 23 November 2004. <www.sciencedaily.com/releases/2004/11/041123102746.htm>.
University Of California - Los Angeles. (2004, November 23). UCLA Brain Researchers Uncover New Clues To SIDS. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2004/11/041123102746.htm
University Of California - Los Angeles. "UCLA Brain Researchers Uncover New Clues To SIDS." ScienceDaily. www.sciencedaily.com/releases/2004/11/041123102746.htm (accessed September 22, 2014).

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