Featured Research

from universities, journals, and other organizations

Risk Of Muscle-damaging Disorder Low For Most Commonly Prescribed Statin Drugs

Date:
December 8, 2004
Source:
Journal Of The American Medical Association
Summary:
Patients taking the lipid-lowering medications atorvastatin, pravastatin, and simvastatin to reduce cholesterol levels, have a relatively low risk of developing rhabdomyolysis, (a disorder that causes the breakdown of muscle), according to a new study in the December 1 issue of JAMA.

Patients taking the lipid-lowering medications atorvastatin, pravastatin, and simvastatin to reduce cholesterol levels, have a relatively low risk of developing rhabdomyolysis, (a disorder that causes the breakdown of muscle), according to a new study in the December 1 issue of JAMA. However, older patients with diabetes mellitus taking combined statin-fibrate therapy appear to be at an increased risk for rhabdomyolysis. And patients who were taking cerivastatin combined with fibrates had a significantly higher risk of about one in 10 treated patients each year. Cerivastatin was removed from the U.S. market in 2001 because of high reporting of rhabdomyolysis in association with its use. The study to be published in the December 1 issue of JAMA is being released early online today because of its relevance to current events.

Disorders of muscle are among the most discussed adverse effects associated with the use of lipid-lowering agents (statins), according to background information in the article. Fibric acid derivatives (fibrates) have also been associated with primary muscle injury, especially when used in combination with a statin.

David J. Graham, M.D., M.P.H., from the Food and Drug Administration, and colleagues, analyzed claims data from 11 managed care health plans across the United States for patients on statins alone (monotherapy) or combined statin-fibrate therapy between January 1, 1998 and June 30, 2001.

"In 252,460 patients treated with lipid-lowering agents, 24 cases of hospitalized rhabdomyolysis occurred during treatment," the researchers report. All patients with rhabdomyolysis were taking statins at daily dosages within the dose-range recommended in product labeling. "Compared with statin monotherapy, fibrate use was associated with a 5.5-fold increase in risk and the combined use of a statin and fibrate increased risk by additional 2-fold vs. fibrate alone," the authors found. "The risk of rhabdomyolysis with cerivastatin monotherapy was 10-fold greater than with other statins, and in combination with a fibrate, was increased more than 1,400-fold."

In conclusion the authors write, "With the potential for substantial increase in the number of patients treated with statins over the next several years, our study provides reassurance that the risk of rhabdomyolysis is relatively low with 3 frequently prescribed statins. For patients treated with both statins and fibrates combined, such as persons with diabetes mellitus with elevated cholesterol and triglyceride levels, the higher risk conferred by combination therapy may warrant that physicians instruct their patients to stop therapy and be evaluated if symptoms suggestive of rhabdomyolysis develop."###

(JAMA. 2004; 292:2585-2590. Available post-embargo at JAMA.com)

Editor's Note: This study was supported by two cooperative agreements from the U.S. Food and Drug Administration. Please see JAMA study for author's financial disclosures.


Story Source:

The above story is based on materials provided by Journal Of The American Medical Association. Note: Materials may be edited for content and length.


Cite This Page:

Journal Of The American Medical Association. "Risk Of Muscle-damaging Disorder Low For Most Commonly Prescribed Statin Drugs." ScienceDaily. ScienceDaily, 8 December 2004. <www.sciencedaily.com/releases/2004/11/041124155424.htm>.
Journal Of The American Medical Association. (2004, December 8). Risk Of Muscle-damaging Disorder Low For Most Commonly Prescribed Statin Drugs. ScienceDaily. Retrieved September 14, 2014 from www.sciencedaily.com/releases/2004/11/041124155424.htm
Journal Of The American Medical Association. "Risk Of Muscle-damaging Disorder Low For Most Commonly Prescribed Statin Drugs." ScienceDaily. www.sciencedaily.com/releases/2004/11/041124155424.htm (accessed September 14, 2014).

Share This



More Health & Medicine News

Sunday, September 14, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Respiratory Virus Spreads To Northeast, Now In 21 States

Respiratory Virus Spreads To Northeast, Now In 21 States

Newsy (Sep. 14, 2014) The respiratory virus Enterovirus D68, which targets children, has spread from the Midwest to 21 states. Video provided by Newsy
Powered by NewsLook.com
Shocker: Journalists Are Utterly Addicted To Coffee

Shocker: Journalists Are Utterly Addicted To Coffee

Newsy (Sep. 13, 2014) A U.K. survey found that journalists consumed the most amount of coffee, but that's only the tip of the coffee-related statistics iceberg. Video provided by Newsy
Powered by NewsLook.com
Contagious Respiratory Illness Continues to Spread Across U.S.

Contagious Respiratory Illness Continues to Spread Across U.S.

Reuters - US Online Video (Sep. 12, 2014) Hundreds of children in several states have been stricken by a serious respiratory illness that is spreading across the U.S. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Batters Sierra Leone Economy Too

Ebola Batters Sierra Leone Economy Too

Reuters - Business Video Online (Sep. 12, 2014) The World Health Organisation warns that local health workers in West Africa can't keep up with Ebola - and among those countries hardest hit by the outbreak, the economic damage is coming into focus, too. As David Pollard reports, Sierra Leone admits that growth in one of the poorest economies in the region is taking a beating. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins