Featured Research

from universities, journals, and other organizations

Disoriented T Cells Cause Liver Disease

Date:
December 7, 2004
Source:
Journal Of Experimental Medicine
Summary:
T cells activated in the gut during inflammatory bowel disease can be re-routed to the liver and cause chronic liver disease, according to Eksteen and colleagues in the December 1 issue of The Journal of Experimental Medicine.

T cells activated in the gut during inflammatory bowel disease can be re-routed to the liver and cause chronic liver disease, according to Eksteen and colleagues in the December 1 issue of The Journal of Experimental Medicine.

Related Articles


A chronic liver disease known as primary sclerosing cholangitis (PSC) has been linked to inflammatory bowel disease (IBD) in the past. But the connection between the two disorders has been unclear, especially as the liver condition often develops years after IBD has resolved or the colon has been surgically removed. Eksteen and colleagues now show that T cells that were activated in the gut – probably during IBD - are found in the livers of patients with PSC, but not in those of patients with other inflammatory liver diseases.

The authors explain this detour by showing that an attractant protein that normally directs T cells into the gut is aberrantly produced in the liver during PSC. T cells expressing the receptor for the protein are thus re-routed to the liver, although the authors do not know what triggers liver cells to make the attractant in the first place. T cells can survive as memory cells for many years after they are activated, and the authors believe this may explain how the liver disease can crop up years after IBD has resolved.


Story Source:

The above story is based on materials provided by Journal Of Experimental Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Journal Of Experimental Medicine. "Disoriented T Cells Cause Liver Disease." ScienceDaily. ScienceDaily, 7 December 2004. <www.sciencedaily.com/releases/2004/11/041129110607.htm>.
Journal Of Experimental Medicine. (2004, December 7). Disoriented T Cells Cause Liver Disease. ScienceDaily. Retrieved October 26, 2014 from www.sciencedaily.com/releases/2004/11/041129110607.htm
Journal Of Experimental Medicine. "Disoriented T Cells Cause Liver Disease." ScienceDaily. www.sciencedaily.com/releases/2004/11/041129110607.htm (accessed October 26, 2014).

Share This



More Health & Medicine News

Sunday, October 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
Toxin-Packed Stem Cells Used To Kill Cancer

Toxin-Packed Stem Cells Used To Kill Cancer

Newsy (Oct. 25, 2014) — A Harvard University Research Team created genetically engineered stem cells that are able to kill cancer cells, while leaving other cells unharmed. Video provided by Newsy
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins