Featured Research

from universities, journals, and other organizations

New Drug Delivery System For Treating Cancer Tested In Animals

Date:
December 15, 2004
Source:
Johns Hopkins Medical Institutions
Summary:
Johns Hopkins researchers led by Jean Geschwind, M.D., associate professor of radiology and radiological science, are testing a novel method for delivering chemotherapeutic agents directly into liver tumors.

Johns Hopkins researchers led by Jean Geschwind, M.D., associate professor of radiology and radiological science, are testing a novel method for delivering chemotherapeutic agents directly into liver tumors.

Related Articles


In the study, catheters were inserted into the femoral artery of rabbits, and tiny beads, impregnated with the anticancer drug doxorubicin, were injected into the tumors. Control animals received intra-arterial injections of the drug alone. Plasma and tissue concentrations of doxorubicin were measured at 1, 12 and 24 hours and 3, 7 and 14 days following treatment.

In the animals treated with the doxorubicin-eluting beads, the concentration of doxorubicin within the tumor was greatest in the 7-day group, followed by the 3-day group, and remained high in the 14-day group, suggesting continuous emission of doxorubicin from the beads. In contrast, the plasma concentrations of the drug were low at all time points, indicating high retention of doxorubicin within the tumor and a lessening risk of systemic toxicity.

The greatest degree of tumor destruction was seen in the 7- to 14-day group. In contrast, control animals had markedly high plasma concentrations of the drug and low concentration of the agent in the tumor, which washed out of the tumor within an hour.

Due to its reduced systemic toxicity and greater tumor-killing efficacy, the researchers say the technique offers a potentially effective new approach to treating certain tumors in humans.


Story Source:

The above story is based on materials provided by Johns Hopkins Medical Institutions. Note: Materials may be edited for content and length.


Cite This Page:

Johns Hopkins Medical Institutions. "New Drug Delivery System For Treating Cancer Tested In Animals." ScienceDaily. ScienceDaily, 15 December 2004. <www.sciencedaily.com/releases/2004/12/041208083740.htm>.
Johns Hopkins Medical Institutions. (2004, December 15). New Drug Delivery System For Treating Cancer Tested In Animals. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2004/12/041208083740.htm
Johns Hopkins Medical Institutions. "New Drug Delivery System For Treating Cancer Tested In Animals." ScienceDaily. www.sciencedaily.com/releases/2004/12/041208083740.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins