Featured Research

from universities, journals, and other organizations

Researchers Set New Standard Of Care For Adult Cord Blood Transplant Patients

Date:
December 16, 2004
Source:
University Of Minnesota
Summary:
University of Minnesota researchers will present the promising results from adult umbilical cord blood studies for patients with cancers of the blood and bone marrow. These studies' findings provide solutions to the problems outlined in recently published studies in the New England Journal of Medicine (NEJM).

University of Minnesota researchers will present the promising results from adult umbilical cord blood studies for patients with cancers of the blood and bone marrow. These studies' findings provide solutions to the problems outlined in recently published studies in the New England Journal of Medicine (NEJM).

"The results of our studies are a triumph in a treatment that has been largely viewed as only possible in children and adolescents," said John Wagner, M.D., professor of pediatrics and scientific director of clinical research, Blood and Marrow Transplantation Program and Stem Cell Institute.

A major limitation of adult cord blood transplantation highlighted in the NEJM articles is the high likelihood of patients dying early after transplant. This likelihood is due to: poor recovery of the patient's blood cell counts as a result of the relatively low number of cells in cord blood compared to bone marrow, or toxicity from the high doses of chemotherapy and radiation used in conventional transplant regimens.

The University of Minnesota Blood and Marrow Transplant Program have addressed these issues in two separate studies. In the first study, the combined use of two cord blood units from different donors was investigated as a way to increase the number of cord blood cells given to the patient on transplant day. Thirty-one patients were given high-dose chemotherapy and radiation, in which all the patient's bone marrow is destroyed, and then transplanted with two partially matched umbilical cords. The matching criteria is less stringent in cord blood than bone marrow. All of the patients engrafted successfully with cord blood cells with a low incidence of serious transplant complications and very promising survival compared to the previous studies.

In the second study, a group of 59 patients who were not eligible for high doses of chemotherapy and radiation (due to their older age, extensive prior chemotherapy treatment, or other serious co-existing diseases) were treated with a "reduced intensity" regimen involving lower doses of chemotherapy and radiation. These patients were then transplanted with cord blood from either one or two donors. In this study, 89 percent of the patients engrafted successfully overall with 98 percent of patients engrafting if they had recent chemotherapy before the transplant or a prior transplant. Despite the high-risk nature of this patient group, the risk of life-threatening transplant complications was relatively low even in older patients or those with a prior transplant.

"These remarkable results represent a significant advance in the practice of adult cord blood transplantation. These approaches allow us to offer potentially life-saving transplant therapy to many patients who have previously been denied such treatment," said Juliet Barker, MBBS(Hons), assistant professor of medicine, Adult Blood and Marrow Transplant Program.

###

The studies were funded by the National Institutes of Health. The study on transplants from two partially HLA-matched umbilical cord blood units is being published in the February print edition of the journal Blood and is currently available online at www.bloodjournal.org.

The Academic Health Center is home to the University of Minnesota's six health professional schools and colleges as well as several health-related centers and institutes. Founded in 1851, the University is one of the oldest and largest land grant institutions in the country. The AHC prepares the new health professionals who improve the health of communities, discover and deliver new treatments and cures, and strengthen the health economy.


Story Source:

The above story is based on materials provided by University Of Minnesota. Note: Materials may be edited for content and length.


Cite This Page:

University Of Minnesota. "Researchers Set New Standard Of Care For Adult Cord Blood Transplant Patients." ScienceDaily. ScienceDaily, 16 December 2004. <www.sciencedaily.com/releases/2004/12/041208084434.htm>.
University Of Minnesota. (2004, December 16). Researchers Set New Standard Of Care For Adult Cord Blood Transplant Patients. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2004/12/041208084434.htm
University Of Minnesota. "Researchers Set New Standard Of Care For Adult Cord Blood Transplant Patients." ScienceDaily. www.sciencedaily.com/releases/2004/12/041208084434.htm (accessed September 20, 2014).

Share This



More Health & Medicine News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins