Featured Research

from universities, journals, and other organizations

Killer Cells May Provide Hope For Leukemia

Date:
December 16, 2004
Source:
University Of Minnesota Academic Health Center
Summary:
A University of Minnesota Cancer Center study indicates natural killer cells obtained from a family member and artificially stimulated may provide renewed hope for some patients who have advanced acute myelogenous leukemia (AML), a highly fatal cancer of the bone marrow, that has become resistant to standard treatment with chemotherapy.

SAN DIEGO, CALIF. (Dec. 5, 2004) -- A University of Minnesota Cancer Center study indicates natural killer cells obtained from a family member and artificially stimulated may provide renewed hope for some patients who have advanced acute myelogenous leukemia (AML), a highly fatal cancer of the bone marrow, that has become resistant to standard treatment with chemotherapy.

Related Articles


Natural killer cells are part of the body’s immune system. The cells play an important role in defending the body against infection and against some cancers, particularly leukemia. In patients with AML, the killer cells have lost most of their natural ability to fight the aggressive cancer cells.

This study is the first to successfully demonstrate that half-matched donor (haploidentical) natural killer cells that are transfused into a patient with AML can survive and persist to actively attack and kill the deadly cancer cells. As a result, the disease may go into remission and make the patient eligible for bone marrow transplant, an effective long-term treatment option for AML.

Jeffrey Miller, M.D., lead researcher, will present the findings of this study – the successful remission of poor prognosis AML patients after transfer of human haploidentical natural killer cells – at the 46th annual meeting of the American Society of Hematology (ASH) on Dec. 5 in San Diego. A hematology physician-researcher, Miller is a professor of medicine at the University of Minnesota Medical School and leader of The Cancer Center’s Blood and Marrow Transplant Program.

According to Miller, the goal of the study was to try to stimulate the immune system of patients with advanced AML to fight the cancer by giving the patients natural killer cells that were donated by family members and activated by a drug called interleukin-2. (Typically, interleukin-2 is a protein substance naturally produced by the body to stimulate natural killer cells and other cells to do their job of fighting infections and cancer. However, in patients with AML, the cancer may suppress the ability of interleukin-2 to optimally stimulate the patient’s own natural killer cells.)

The result of Miller’s study was this: the donated natural killer cells thrived in some patients for more than 28 days, and five of 19 patients achieved remission.

“Admittedly we need to do more research, but we believe that we may have found another option, opened another door to potentially broaden our treatment capabilities of AML and give more hope to some patients who have been told there was nothing more that could be done for them,” Miller says.

AML is the most common acute leukemia. In people over age 65, AML has increased about 10 percent in the last 25 years. Of the nearly 12,000 people who will be diagnosed with AML this year, about 90 percent will be adults age 65 and older. Approximately 8,870 people with AML will die this year.

Miller and his research team found in previous studies that natural killer cells derived from the patient did not provide the anti-tumor effect. In this study, the team set out to determine if natural killer cells that were obtained from a family member, artificially stimulated with interleukin-2 and then infused into the patient could have an anti-tumor effect.

A total of 19 patients with AML were compared to a control group of eight patients with renal cancer. The patients with renal cancer received a low intensity outpatient immune suppressive dose of the chemotherapy drug, fludarabine. The patients with AML received a higher intensity inpatient treatment of the chemotherapy drugs, cyclophosphamide and fludarabine. Both sets of patients received interleukin-2, a protein substance that makes infection-fighting cells multiply and mature. The data showed that the infused natural killer cells expanded in the AML patients to achieve anti-tumor efficacy. There were no notable responses in the patients with renal cancer.

Additionally, the study indicated that interleukin-15, also a protein substance and similar to interleukin-2, played a role in the expansion of the natural killer cells. Patients with AML had significant increases in their interleukin-15, while renal cancer patients in the control group showed only a slight increase. This finding suggested that the chemotherapy combination of cyclophosphamide and fludarabine allowed for the expansion of infused natural killer cells.

“We are encouraged by our findings,” Miller says. “Now we have data indicating that haploidentical natural killer cells have a role in the treatment of AML, whether used alone or in combination with a bone marrow transplant.”

This study was funded by a research grant from the National Cancer Institute.


Story Source:

The above story is based on materials provided by University Of Minnesota Academic Health Center. Note: Materials may be edited for content and length.


Cite This Page:

University Of Minnesota Academic Health Center. "Killer Cells May Provide Hope For Leukemia." ScienceDaily. ScienceDaily, 16 December 2004. <www.sciencedaily.com/releases/2004/12/041208084536.htm>.
University Of Minnesota Academic Health Center. (2004, December 16). Killer Cells May Provide Hope For Leukemia. ScienceDaily. Retrieved October 26, 2014 from www.sciencedaily.com/releases/2004/12/041208084536.htm
University Of Minnesota Academic Health Center. "Killer Cells May Provide Hope For Leukemia." ScienceDaily. www.sciencedaily.com/releases/2004/12/041208084536.htm (accessed October 26, 2014).

Share This



More Health & Medicine News

Sunday, October 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
Toxin-Packed Stem Cells Used To Kill Cancer

Toxin-Packed Stem Cells Used To Kill Cancer

Newsy (Oct. 25, 2014) — A Harvard University Research Team created genetically engineered stem cells that are able to kill cancer cells, while leaving other cells unharmed. Video provided by Newsy
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins