Featured Research

from universities, journals, and other organizations

New Molecular Classification Of Breast Cancer Predicts Response To Chemotherapy

Date:
December 13, 2004
Source:
M.D. Anderson Cancer Center, University Of Texas
Summary:
Different molecular subtypes of breast cancer respond differently to chemotherapy, a research team from The University of Texas M. D. Anderson Cancer Center reported at the annual San Antonio Breast Cancer Symposium meeting.

Different molecular subtypes of breast cancer respond differently to chemotherapy, a research team from The University of Texas M. D. Anderson Cancer Center reported at the annual San Antonio Breast Cancer Symposium meeting.

The findings reinforce the emerging notion that breast cancer should be classified according to its gene expression profile, in order to make accurate predictions about the outcome of the disease and select the optimal treatment for patients, says the senior investigator, Lajos Pusztai, M.D., Ph.D., an associate professor in the Department of Breast Medical Oncology.

Four major molecular subgroups of breast cancer ? normal-like, luminal (ER-positive), basal-like (mostly ER-negative), or erbb2+ (mostly HER-2 amplified) ? have been previously defined, based on expression of 424 genes involved in cancer development. Scientists have already shown that each subgroup has a different prognosis. In this recent study Pusztai and his group looked at whether these molecular subgroups also respond differently to chemotherapy that is delivered before surgery.

The research team obtained tumor tissue biopsies from 82 patients with newly diagnosed breast cancer before they were given a commonly used chemotherapy (Taxol/FAC). Patients with basal-like and erbb2+ subgroups were found to have the highest rates (45 percent each) of a pathological complete response, while only 6 percent of luminal tumors had a complete response. Among the normal-like cancers, no response was seen.

They then looked at the genes associated with response in basal-like and erbb2+ patients and found that they were different, "suggesting that the mechanisms of chemotherapy sensitivity may be unique to a subgroup," Pusztai says.

"This is of great interest because it suggests that stratification of patients into molecular subgroups may be needed in order to develop the most accurate predictors of treatment response," he says. "Different sets of genes present in different molecular subgroups may determine the response to a particular regimen of chemotherapy."


Story Source:

The above story is based on materials provided by M.D. Anderson Cancer Center, University Of Texas. Note: Materials may be edited for content and length.


Cite This Page:

M.D. Anderson Cancer Center, University Of Texas. "New Molecular Classification Of Breast Cancer Predicts Response To Chemotherapy." ScienceDaily. ScienceDaily, 13 December 2004. <www.sciencedaily.com/releases/2004/12/041209000023.htm>.
M.D. Anderson Cancer Center, University Of Texas. (2004, December 13). New Molecular Classification Of Breast Cancer Predicts Response To Chemotherapy. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2004/12/041209000023.htm
M.D. Anderson Cancer Center, University Of Texas. "New Molecular Classification Of Breast Cancer Predicts Response To Chemotherapy." ScienceDaily. www.sciencedaily.com/releases/2004/12/041209000023.htm (accessed August 27, 2014).

Share This




More Health & Medicine News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Predicting Heart Transplant Rejection With a Blood Test

Predicting Heart Transplant Rejection With a Blood Test

Ivanhoe (Aug. 27, 2014) Now a new approach to rejection of donor organs could change the way doctors predict transplant rejection…without expensive, invasive procedures. Video provided by Ivanhoe
Powered by NewsLook.com
Better Braces That Vibrate

Better Braces That Vibrate

Ivanhoe (Aug. 27, 2014) The length of time you have to keep your braces on could be cut in half thanks to a new device that speeds up the process. Video provided by Ivanhoe
Powered by NewsLook.com
Smartphone App Tracks Your Heart Rate

Smartphone App Tracks Your Heart Rate

Ivanhoe (Aug. 27, 2014) A new app that can track your heart rate 24/7 is available for download in your app store and its convenience could save your life. Video provided by Ivanhoe
Powered by NewsLook.com
Stroke in Young Adults

Stroke in Young Adults

Ivanhoe (Aug. 27, 2014) A stroke can happen at any time and affect anyone regardless of age. This mother chose to give her son independence and continue to live a normal life after he had a stroke at 18 years old. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins