Featured Research

from universities, journals, and other organizations

Research Finds Genetic Link To Antidepressants

Date:
January 3, 2005
Source:
University Of California - Los Angeles
Summary:
Researchers in recent years have been trying to identify genetic factors predicting a response to antidepressants. Previous studies have found evidence for the role of corticotrophin-releasing hormone (CRH) in depression.

Researchers in recent years have been trying to identify genetic factors predicting a response to antidepressants. Previous studies have found evidence for the role of corticotrophin-releasing hormone (CRH) in depression. Based on previous findings, researchers have most closely focused on drugs that target serotonin transports, such as Prozac. None of these studies, however, focused on specific demographic groups such as Mexican-Americans or on stress-related genes such as CRH.

Related Articles


Basing their study on 80 depressed Mexican-Americans in Los Angeles, the researchers found that depressed and highly anxious patients with a variant of the CRH gene (CRHR1) had a 70 percent greater reduction in anxiety and a 30 percent greater reduction in depression in response to the anti-depressants Prozac and desipramine than did patients without the gene variation in question.

The findings for the first time show an association between responses to specific anti-depressants and a stress-related gene. Physicians have generally taken a "hit and miss" approach to prescribing anti-depressants. The findings show promise in helping physicians tailor prescriptions to specific people.

The lead author was Julio Licinio, professor of psychiatric and biobehavioral sciences at the David Geffen School of Medicine at UCLA.

###

JOURNAL: Molecular Psychiatry, available online Dec. 16 at www.nature.com/mp.

FUNDERS: National Institutes of Health and the Dana Foundation.


Story Source:

The above story is based on materials provided by University Of California - Los Angeles. Note: Materials may be edited for content and length.


Cite This Page:

University Of California - Los Angeles. "Research Finds Genetic Link To Antidepressants." ScienceDaily. ScienceDaily, 3 January 2005. <www.sciencedaily.com/releases/2004/12/041219172416.htm>.
University Of California - Los Angeles. (2005, January 3). Research Finds Genetic Link To Antidepressants. ScienceDaily. Retrieved March 28, 2015 from www.sciencedaily.com/releases/2004/12/041219172416.htm
University Of California - Los Angeles. "Research Finds Genetic Link To Antidepressants." ScienceDaily. www.sciencedaily.com/releases/2004/12/041219172416.htm (accessed March 28, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Saturday, March 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

AAA: Distracted Driving a Serious Teen Problem

AAA: Distracted Driving a Serious Teen Problem

AP (Mar. 25, 2015) While distracted driving is not a new problem for teens, new research from the AAA Foundation for Traffic Safety says it&apos;s much more serious than previously thought. (March 25) Video provided by AP
Powered by NewsLook.com
Smartphone Use Changing Our Brain and Thumb Interaction, Say Researchers

Smartphone Use Changing Our Brain and Thumb Interaction, Say Researchers

Reuters - Innovations Video Online (Mar. 25, 2015) European researchers say our smartphone use offers scientists an ideal testing ground for human brain plasticity. Dr Ako Ghosh&apos;s team discovered that the brains and thumbs of smartphone users interact differently from those who use old-fashioned handsets. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Many Don't Know They Have Alzheimer's, But Their Doctors Do

Many Don't Know They Have Alzheimer's, But Their Doctors Do

Newsy (Mar. 24, 2015) According to a new study by the Alzheimer&apos;s Association, more than half of those who have the degenerative brain disease aren&apos;t told by their doctors. Video provided by Newsy
Powered by NewsLook.com
A Quick 45-Minute Nap Can Improve Your Memory

A Quick 45-Minute Nap Can Improve Your Memory

Newsy (Mar. 23, 2015) Researchers found those who napped for 45 minutes to an hour before being tested on information recalled it five times better than those who didn&apos;t. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins