Featured Research

from universities, journals, and other organizations

Neural Crest Stem Cells In Skin Could Provide Alternative To Embryonic Stem Cell Use

Date:
December 23, 2004
Source:
John Wiley & Sons, Inc.
Summary:
Cell replacement therapy offers a novel and powerful medical technology. A type of embryonic stem cell, called a neural crest stem cell, that persists into adulthood in hair follicles was recently discovered by Maya Sieber-Blum, Ph.D., of the Medical College of Wisconsin, Milos Grim, MD Ph.D., of Charles University Prague, and their collaborators.

Cell replacement therapy offers a novel and powerful medical technology. A type of embryonic stem cell, called a neural crest stem cell, that persists into adulthood in hair follicles was recently discovered by Maya Sieber-Blum, Ph.D., of the Medical College of Wisconsin, Milos Grim, MD Ph.D., of Charles University Prague, and their collaborators.

Related Articles


The discovery – reported recently in Developmental Dynamics, a journal of the American Association of Anatomists published by John Wiley & Sons, Inc. – may in many instances provide a non-controversial substitute for embryonic stem cells. Embryonic stem cells are unique, because they can differentiate into any cell type of the body. Their use, however, raises ethical concerns because embryos are being destroyed in the process. In contrast, neural crest stem cells from adults have several advantages: similar to embryonic stem cells, they have the innate ability to differentiate into many diverse cell types; they are easily accessible in the skin of adults; and the patient's own neural crest stem cells could be used for cell therapy. The latter avoids both rejection of the implant and graft-versus-host disease.

Studies in the mouse showed that neural crest stem cells from adult hair follicles are able to differentiate into neurons, nerve supporting cells, cartilage/bone cells, smooth muscle cells, and pigment cells. Preliminary data indicate that equivalent stem cells reside in human hair follicles.

"The goal of our research is to apply neural crest stem cells from adult hair follicles in cell replacement therapy in selected instances," Sieber-Blum says. This may include, spinal cord injury, Parkinson's disease, multiple sclerosis, Hirschsprung's disease, peripheral neuropathies, certain defects of the heart, and bone degeneration. Though promising, this research is still in the animal testing stage. Additional research is required before it could benefit patients.

###

Sieber-Blum will present these findings at the American Association of Anatomists' Annual Meeting at Experimental Biology (EB) 2005 at a session on "Stem Cells in the Adult Epidermis" (Wednesday, April 6, 10:30 a.m.-12:30 p.m., San Diego Convention Center).

Article: "Pluripotent neural crest stem cells in the adult hair follicle (p 258-269) M. Sieber-Blum, M. Grim, Y.F. Hu, V. Szeder, Developmental Dynamics; Volume 231, Issue 2 (October 2004)Published Online: July 28, 2004 (DOI: 10.1002/dvdy.20129).


Story Source:

The above story is based on materials provided by John Wiley & Sons, Inc.. Note: Materials may be edited for content and length.


Cite This Page:

John Wiley & Sons, Inc.. "Neural Crest Stem Cells In Skin Could Provide Alternative To Embryonic Stem Cell Use." ScienceDaily. ScienceDaily, 23 December 2004. <www.sciencedaily.com/releases/2004/12/041220031543.htm>.
John Wiley & Sons, Inc.. (2004, December 23). Neural Crest Stem Cells In Skin Could Provide Alternative To Embryonic Stem Cell Use. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2004/12/041220031543.htm
John Wiley & Sons, Inc.. "Neural Crest Stem Cells In Skin Could Provide Alternative To Embryonic Stem Cell Use." ScienceDaily. www.sciencedaily.com/releases/2004/12/041220031543.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) — The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins