Featured Research

from universities, journals, and other organizations

Getting Cancer Therapy Into The Bones

Date:
January 12, 2005
Source:
Weizmann Institute
Summary:
When prostate cancer, one of the leading causes of cancer death among men, spreads in the body, it most often goes to the bone where it is particularly difficult to treat. Metastasis to the bone is implicated in over 70% of prostate cancer deaths. Prof. Zelig Eshhar, Head of the Immunology Department at the Weizmann Institute of Science, has now shown how a treatment that works on cancer in the prostate can be redirected to the bones.

When prostate cancer, one of the leading causes of cancer death among men, spreads in the body, it most often goes to the bone where it is particularly difficult to treat. Metastasis to the bone is implicated in over 70% of prostate cancer deaths. Prof. Zelig Eshhar, Head of the Immunology Department at the Weizmann Institute of Science, has now shown how a treatment that works on cancer in the prostate can be redirected to the bones.

Related Articles


The treatment, which was developed in Eshhar’s lab a number of years ago, is based on cells that have been engineered to combine two different types of weapons used by the immune system to fight invaders. Antibodies are best at recognizing foreign or altered molecules such as antigens on the outer walls of bacteria, viruses or cancer cells. T cells are better at killing unwanted cells, but not as adept at identification, especially of tricky cancer cells that may already have developed methods of evading detection by the immune system. By attaching an antibody-based structure designed to recognize specific cancer cells directly to a T cell receptor, Eshhar produced custom-modified cells, dubbed T bodies, which are proficient at both finding and killing cancer cells.

However, getting T bodies into the bone to treat metastasized cancer was another story. The cancer in this case is likely to be spread throughout the bone, in hard to reach places. When Eshhar’s research team first injected T bodies into immunodeficient mice in which human prostate cancer developed in the leg bones, they saw no real improvement, indicating to them that the cells were not getting to the cancer in significant enough quantities to have an effect.

To address the problem, the Weizmann team, which included Dr. Jehonathan Pinthus of Sheba Medical Center, Tel Hashomer, “preconditioned” the mice using one of two strategies already in use in some forms of cancer therapy: low doses of radiation or a specific chemotherapy drug. Both treatments cause some disruption in the bone marrow, the intended target of the T bodies. In response, the bone marrow sends out a chemical distress signal to the immune system. This signal not only alerts immune cells such as T cells to the danger, but assists them in homing in on the problem area and in passing through barriers that might otherwise prevent them from getting into the bone marrow tissue.

Mice treated with either therapy 24 hours prior to being injected with T bodies showed a significant drop in the tumor marker, PSA (an indicator of cancer levels), a reduction in the tumor load and prolonged survival. Because the method holds promise for treating disseminated cancers that are resistant to other forms of therapy, Eshhar hopes to move it into clinical trials in the near future.

Prof. Zelig Eshhar's research is supported by the M.D. Moross Institute for Cancer Research and the Crown Endowment Fund for Immunological Research.

Prof. Eshhar is the incumbent of the Marshall & Renette Ezralow Professorial Chair of Chemical & Cellular Immunology.


Story Source:

The above story is based on materials provided by Weizmann Institute. Note: Materials may be edited for content and length.


Cite This Page:

Weizmann Institute. "Getting Cancer Therapy Into The Bones." ScienceDaily. ScienceDaily, 12 January 2005. <www.sciencedaily.com/releases/2005/01/050111183441.htm>.
Weizmann Institute. (2005, January 12). Getting Cancer Therapy Into The Bones. ScienceDaily. Retrieved April 18, 2015 from www.sciencedaily.com/releases/2005/01/050111183441.htm
Weizmann Institute. "Getting Cancer Therapy Into The Bones." ScienceDaily. www.sciencedaily.com/releases/2005/01/050111183441.htm (accessed April 18, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, April 18, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Scientists Find Link Between Gestational Diabetes And Autism

Scientists Find Link Between Gestational Diabetes And Autism

Newsy (Apr. 17, 2015) Researchers who analyzed data from over 300,000 kids and their mothers say they&apos;ve found a link between gestational diabetes and autism. Video provided by Newsy
Powered by NewsLook.com
Video Messages Help Reassure Dementia Patients

Video Messages Help Reassure Dementia Patients

AP (Apr. 17, 2015) Family members are prerecording messages as part of a unique pilot program at the Hebrew Home in New York. The videos are trying to help victims of Alzheimer&apos;s disease and other forms of dementia break through the morning fog of forgetfulness. (April 17) Video provided by AP
Powered by NewsLook.com
Boy or Girl? Intersex Awareness Is on the Rise

Boy or Girl? Intersex Awareness Is on the Rise

AP (Apr. 17, 2015) At least 1 in 5,000 U.S. babies are born each year with intersex conditions _ ambiguous genitals because of genetic glitches or hormone problems. Secrecy and surgery are common. But some doctors and activists are trying to change things. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins