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The Opportunity For Canalization And The Evolution Of Genetic Networks

Date:
February 8, 2005
Source:
University Of Chicago Press Journals
Summary:
The recent explosion of genomic data has inspired a renewed interest in how groups of genes work together to create observable phenotypes. Studies of genetic networks have shown a surprising degree of robustness to variation, regardless of whether the variation comes from a change within or outside of the network.
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The recent explosion of genomic data has inspired a renewed interest in how groups of genes work together to create observable phenotypes. Studies of genetic networks have shown a surprising degree of robustness to variation, regardless of whether the variation comes from a change within or outside of the network.

One explanation for this pattern is that evolution has acted to create genetic networks that are robust to mutational defects at single genes within the network. Using a combination of mathematical and computational models, Stephen R. Proulx and Patrick C. Phillips investigate the evolution of genetic networks in response to a variety of genetic and environmental perturbations. The models show that natural selection for robustness will only be as strong as the cost of disrupting the network. Because the risk of mutational damage is limited by the mutation rate, these results imply that robustness to mutation will play only a small part in the evolution of genetic networks.

Environmental perturbations, on the other hand, can affect large fractions of a population and are thus more likely to play a significant role in genetic network evolution.

This article will appear in the February 2005 issue of American Naturalist.


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The above post is reprinted from materials provided by University Of Chicago Press Journals. Note: Materials may be edited for content and length.


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University Of Chicago Press Journals. "The Opportunity For Canalization And The Evolution Of Genetic Networks." ScienceDaily. ScienceDaily, 8 February 2005. <www.sciencedaily.com/releases/2005/02/050205073412.htm>.
University Of Chicago Press Journals. (2005, February 8). The Opportunity For Canalization And The Evolution Of Genetic Networks. ScienceDaily. Retrieved July 31, 2015 from www.sciencedaily.com/releases/2005/02/050205073412.htm
University Of Chicago Press Journals. "The Opportunity For Canalization And The Evolution Of Genetic Networks." ScienceDaily. www.sciencedaily.com/releases/2005/02/050205073412.htm (accessed July 31, 2015).

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