Featured Research

from universities, journals, and other organizations

Premature Births From Inflammation And Infection Rapidly Detected By Proteomics Technology

Date:
February 8, 2005
Source:
Yale University
Summary:
A combination of four proteins that result from inflammation and infection and lead to premature birth can be rapidly and accurately detected in the amniotic fluid of pregnant women using proteomics technology, Yale researchers report in two studies in the February issue of British Journal of Obstetrics and Gynecology.

New Haven, Conn. -- A combination of four proteins that result from inflammation and infection and lead to premature birth can be rapidly and accurately detected in the amniotic fluid of pregnant women using proteomics technology, Yale researchers report in two studies in the February issue of British Journal of Obstetrics and Gynecology.

Related Articles


Using proteomics science, the Yale team, in collaboration with two other academic institutions, developed a novel method called MR scoring to discriminate healthy from diseased women in whom preterm delivery is impending and the health of the fetus is in danger. MR scoring relies on identification of a group of proteins that serve as biomarkers characteristic to women who will deliver preterm. The proteins detected are Human neutrophil defensin 1, Human neutrophil defensin 2, Calgranulin C and Calgranulin A.

"We are probably at a turning point in the history of preterm labor diagnosis," said Irina Buhimschi, M.D., research scientist in the Department of Obstetrics & Gynecology and Reproductive Sciences. "While many proteins are present in the amniotic fluid, not all are biomarkers with diagnostic significance."

About 50 percent of women who deliver prematurely have evidence of inflammation in the amniotic fluid. In the current study, Buhimschi and co-authors analyzed stored samples of amniotic fluid from 107 women, some diagnosed with rupture of the membranes or twins and eventually delivered prematurely. The sensitivity and specificity of the MR score in identifying women who had infection and inflammation and delivered earlier reached 100 percent. The four biomarkers are necessary and sufficient to separate between sick and healthy patients.

Buhimschi said the current "gold standard" for infection consists of amniotic fluid culture, which takes days to obtain results. A proteomic diagnostic test for infection and inflammation could probably be performed much faster than the current available laboratory tests. Other current tests have poor sensitivity and specificity and are not available in time for rapid clinical decisions.

The team will present another clinical application of their research (cervical incompetence) during the Plenary Session in February at the 2005 Annual Meeting of the Society for Maternal Fetal Medicine in Reno, Nevada. Other authors include Catalin Buhimschi, M.D. of Yale, Rob Christner of Ciphergen Biosystems and Carl P. Weiner of University of Maryland. The study was funded by the National Institutes of Health and Ciphergen Biosystems.

Citation: British Journal of Obstetrics and Gynecology, Vol. 112 p. 173-181; 250-255.


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Premature Births From Inflammation And Infection Rapidly Detected By Proteomics Technology." ScienceDaily. ScienceDaily, 8 February 2005. <www.sciencedaily.com/releases/2005/02/050205105443.htm>.
Yale University. (2005, February 8). Premature Births From Inflammation And Infection Rapidly Detected By Proteomics Technology. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2005/02/050205105443.htm
Yale University. "Premature Births From Inflammation And Infection Rapidly Detected By Proteomics Technology." ScienceDaily. www.sciencedaily.com/releases/2005/02/050205105443.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins