Featured Research

from universities, journals, and other organizations

The Very Unexpected Life And Death Of A Leukemic Cell

Date:
February 16, 2005
Source:
Journal Of Clinical Investigation
Summary:
For years, doctors and scientists believed that B cell chronic lymphocytic leukemia (CLL) was a static disease of long-lived lymphocytes -- that the leukemia cells were both immortal and born at a slow rate, causing the slow rise in cell count over time. But researchers had been unable to find any problems with the programmed cell death machinery in CLL cells.

B cell chronic lymphocytic leukemia (CLL) is an incurable disease in which cells in the bone marrow grow and survive to the point where they become abnormal and malignant (leukemic). The progression of the disease is slow and there has been a lack of information regarding the rate of production of CLL cells, and the time-course of their death.

Related Articles


For years, doctors and scientists believed that CLL was a static disease of long-lived lymphocytes -- that the leukemia cells were both immortal and born at a slow rate, causing the slow rise in cell count over time. But researchers had been unable to find any problems with the programmed cell death machinery in CLL cells. This was a hint that perhaps the leukemia cells were not immortal, a hypothesis tested by Nicholas Chiorazzi and colleagues in a paper appearing online on February 10 in advance of publication in the March 1 print edition of the Journal of Clinical Investigation. This new study shows that leukemia cells are born at a fast rate and do indeed die. The slow rise in the cell count over time can be attributed to the difference between the birth and death rates of the cells, according to the study.

The researchers at the Institute for Medical Research at North Shore-LIJ analyzed the kinetics of CLL cells in vivo by employing a non-radioactive labeling technique – using "heavy water" to track cell production. Heavy water is made using a form of hydrogen that has twice its normal mass, making the water molecule "heavier" than normal. The special hydrogen serves as a tag that enables researchers to track the utilization of water in the body. The hydrogen incorporates into glucose and the tagged glucose eventually makes its way into the cell's DNA.

Researchers gave 19 individuals with CLL a small dose of heavy water every day for 84 days, and the tagged water was incorporated into the DNA of the leukemia cells. This provided the researchers a way to track the cell division, or "birth" of new leukemia cells. Chiorazzi and his team calculated birth and death rates of the leukemic cells and found that, contrary to expectations, production and destruction of CLL cells is highly variable, and does not exhibit a steady birth and death rate as previously thought.

The data also reveal that a correlation exists between the rate at which CLL cells are born and the clinical activity or progression of the disease in a patient. The disease activity may vary over time and this may be the result of fluctuations in birth and/or death rates of the CLL cells.

This challenges the dogma that CLL is a purely accumulative disorder where leukemic cells accumulate because they cannot die. Clearly CLL is a disease in which there is a dynamic interplay between rates of cell division and cell death. The data could enable physicians to predict disease progression.


Story Source:

The above story is based on materials provided by Journal Of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal Of Clinical Investigation. "The Very Unexpected Life And Death Of A Leukemic Cell." ScienceDaily. ScienceDaily, 16 February 2005. <www.sciencedaily.com/releases/2005/02/050212201239.htm>.
Journal Of Clinical Investigation. (2005, February 16). The Very Unexpected Life And Death Of A Leukemic Cell. ScienceDaily. Retrieved March 3, 2015 from www.sciencedaily.com/releases/2005/02/050212201239.htm
Journal Of Clinical Investigation. "The Very Unexpected Life And Death Of A Leukemic Cell." ScienceDaily. www.sciencedaily.com/releases/2005/02/050212201239.htm (accessed March 3, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 3, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mom Triumphs Over Tragedy, Helps Other Families

Mom Triumphs Over Tragedy, Helps Other Families

AP (Mar. 3, 2015) After her son, Dax, died from a rare form of leukemia, Julie Locke decided to give back to the doctors at St. Jude Children&apos;s Research Hospital who tried to save his life. She raised $1.6M to help other patients and their families. (March 3) Video provided by AP
Powered by NewsLook.com
Looted and Leaking, South Sudan's Oil Wells Pose Health Risk

Looted and Leaking, South Sudan's Oil Wells Pose Health Risk

AFP (Mar. 3, 2015) Thick black puddles and a looted, leaking ruin are all that remain of the Thar Jath oil treatment facility, once a crucial part of South Sudan&apos;s mainstay industry. Duration: 01:13 Video provided by AFP
Powered by NewsLook.com
Woman Convicted of Poisoning Son

Woman Convicted of Poisoning Son

AP (Mar. 3, 2015) A woman who blogged for years about her son&apos;s constant health woes was convicted Monday of poisoning him to death by force-feeding heavy concentrations of sodium through his stomach tube. (March 3) Video provided by AP
Powered by NewsLook.com
Treadmill Test Can Predict Chance Of Death Within A Decade

Treadmill Test Can Predict Chance Of Death Within A Decade

Newsy (Mar. 2, 2015) Johns Hopkins researchers analyzed 58,000 heart stress tests to come up with a formula that predicts a person&apos;s chances of dying in the next decade. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins