Featured Research

from universities, journals, and other organizations

Progress Toward A New Remedy For Chronic Urinary Tract Infections?

Date:
February 17, 2005
Source:
Flanders Interuniversity Institute Of Biotechnology
Summary:
Researchers have recently published results that show promise in the quest for a new remedy for chronic urinary tract infections.

Researchers from the Flanders Interuniversity Institute for Biotechnology (VIB) at the Free University of Brussels have recently published results that show promise in the quest for a new remedy for chronic urinary tract infections. The researchers have shown that administration of the sugar Heptyl--D-mannoside can prevent E. coli bacteria from binding to the wall of the urinary tract - which is the first step in the development of the infection.

A widespread problem

Urinary tract and bladder infections are among the most prevalent bacterial infections and can be quite painful. Fifty percent of all women are confronted by these unpleasant infections at some point in their lives. The disorder is an especially severe problem when it becomes chronic - whereby some patients experience symptoms almost continually. The Escherichia coli bacterium is responsible for 80% of these urinary tract infections. Treatment with antibiotics is possible but does not preclude a recurrence of the infection. In addition to this, more and more bacteria are becoming resistant to the antibiotics. For these reasons, scientists have been busy seeking another solution.

Prevention is better than cure

Julie Bouckaert and her co-researchers, under the direction of Henri De Greve, have discovered a way to prevent E. coli bacteria from adhering to the wall of the urinary tract, so that they can no longer cause infection. Because E. coli bacteria use very particular hair-like projections (called pili) to cling to tissues - the first stage of a potential inflammation - a drug that can prevent this attachment can also avert bladder and urinary tract inflammations.

Combating certain bonds

Bouckaert and De Greve have investigated the way in which the E. coli bacteria attach themselves. This attachment takes place by means of a reaction between the protein 'Adhesine FimH' on the tips of the pili and special receptors on the wall of the urinary tract. The researchers hypothesized that they could prevent this binding by administering a substance that would have a greater affinity with Adhesine FimH than with the receptors on the urinary tract. Then, the E. coli binding places would be so captivated by this particular substance that they would no longer be able to cling to the wall of the urinary tract.

Their search for such a substance proved fruitful. Via crystallography and affinity determinations, they demonstrated that the bacteria bind very strongly to the structure of the Heptyl--D-mannoside sugar. This binding is strong enough to prevent the bacteria from attaching themselves to the urinary tract wall. Therefore, administration of Heptyl--D-mannoside could prevent bladder infections. This finding opens possibilities for the development of a new medication for chronic urinary tract infections.


Story Source:

The above story is based on materials provided by Flanders Interuniversity Institute Of Biotechnology. Note: Materials may be edited for content and length.


Cite This Page:

Flanders Interuniversity Institute Of Biotechnology. "Progress Toward A New Remedy For Chronic Urinary Tract Infections?." ScienceDaily. ScienceDaily, 17 February 2005. <www.sciencedaily.com/releases/2005/02/050213121835.htm>.
Flanders Interuniversity Institute Of Biotechnology. (2005, February 17). Progress Toward A New Remedy For Chronic Urinary Tract Infections?. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2005/02/050213121835.htm
Flanders Interuniversity Institute Of Biotechnology. "Progress Toward A New Remedy For Chronic Urinary Tract Infections?." ScienceDaily. www.sciencedaily.com/releases/2005/02/050213121835.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Microneedle Patch Promises Painless Pricks

Microneedle Patch Promises Painless Pricks

Reuters - Innovations Video Online (Oct. 18, 2014) Researchers at The National University of Singapore have invented a new microneedle patch that could offer a faster and less painful delivery of drugs such as insulin and painkillers. Video provided by Reuters
Powered by NewsLook.com
Raw: Nurse Nina Pham Arrives in Maryland

Raw: Nurse Nina Pham Arrives in Maryland

AP (Oct. 17, 2014) The first nurse to be diagnosed with Ebola at a Dallas hospital walked down the stairs of an executive jet into an ambulance at an airport in Frederick, Maryland, on Thursday. Pham will be treated at the National Institutes of Health. (Oct. 16) Video provided by AP
Powered by NewsLook.com
Raw: Cruise Ship Returns to US Over Ebola Fears

Raw: Cruise Ship Returns to US Over Ebola Fears

AP (Oct. 17, 2014) A Caribbean cruise ship carrying a Dallas health care worker who is being monitored for signs of the Ebola virus is heading back to Texas, US, after being refused permission to dock in Cozumel, Mexico. (Oct. 17) Video provided by AP
Powered by NewsLook.com
Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

AFP (Oct. 17, 2014) All four suspected Ebola cases admitted to hospitals in Spain on Thursday have tested negative for the deadly virus in a first round of tests, the government said Friday. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins