Featured Research

from universities, journals, and other organizations

Progress Toward A New Remedy For Chronic Urinary Tract Infections?

Date:
February 17, 2005
Source:
Flanders Interuniversity Institute Of Biotechnology
Summary:
Researchers have recently published results that show promise in the quest for a new remedy for chronic urinary tract infections.

Researchers from the Flanders Interuniversity Institute for Biotechnology (VIB) at the Free University of Brussels have recently published results that show promise in the quest for a new remedy for chronic urinary tract infections. The researchers have shown that administration of the sugar Heptyl--D-mannoside can prevent E. coli bacteria from binding to the wall of the urinary tract - which is the first step in the development of the infection.

Related Articles


A widespread problem

Urinary tract and bladder infections are among the most prevalent bacterial infections and can be quite painful. Fifty percent of all women are confronted by these unpleasant infections at some point in their lives. The disorder is an especially severe problem when it becomes chronic - whereby some patients experience symptoms almost continually. The Escherichia coli bacterium is responsible for 80% of these urinary tract infections. Treatment with antibiotics is possible but does not preclude a recurrence of the infection. In addition to this, more and more bacteria are becoming resistant to the antibiotics. For these reasons, scientists have been busy seeking another solution.

Prevention is better than cure

Julie Bouckaert and her co-researchers, under the direction of Henri De Greve, have discovered a way to prevent E. coli bacteria from adhering to the wall of the urinary tract, so that they can no longer cause infection. Because E. coli bacteria use very particular hair-like projections (called pili) to cling to tissues - the first stage of a potential inflammation - a drug that can prevent this attachment can also avert bladder and urinary tract inflammations.

Combating certain bonds

Bouckaert and De Greve have investigated the way in which the E. coli bacteria attach themselves. This attachment takes place by means of a reaction between the protein 'Adhesine FimH' on the tips of the pili and special receptors on the wall of the urinary tract. The researchers hypothesized that they could prevent this binding by administering a substance that would have a greater affinity with Adhesine FimH than with the receptors on the urinary tract. Then, the E. coli binding places would be so captivated by this particular substance that they would no longer be able to cling to the wall of the urinary tract.

Their search for such a substance proved fruitful. Via crystallography and affinity determinations, they demonstrated that the bacteria bind very strongly to the structure of the Heptyl--D-mannoside sugar. This binding is strong enough to prevent the bacteria from attaching themselves to the urinary tract wall. Therefore, administration of Heptyl--D-mannoside could prevent bladder infections. This finding opens possibilities for the development of a new medication for chronic urinary tract infections.


Story Source:

The above story is based on materials provided by Flanders Interuniversity Institute Of Biotechnology. Note: Materials may be edited for content and length.


Cite This Page:

Flanders Interuniversity Institute Of Biotechnology. "Progress Toward A New Remedy For Chronic Urinary Tract Infections?." ScienceDaily. ScienceDaily, 17 February 2005. <www.sciencedaily.com/releases/2005/02/050213121835.htm>.
Flanders Interuniversity Institute Of Biotechnology. (2005, February 17). Progress Toward A New Remedy For Chronic Urinary Tract Infections?. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2005/02/050213121835.htm
Flanders Interuniversity Institute Of Biotechnology. "Progress Toward A New Remedy For Chronic Urinary Tract Infections?." ScienceDaily. www.sciencedaily.com/releases/2005/02/050213121835.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins