Featured Research

from universities, journals, and other organizations

Mouse Model Of Leukemia Yields Exciting Therapeutic Implications For Rare Childhood Cancer

Date:
February 22, 2005
Source:
Cell Press
Summary:
A new study provides direct evidence that mutations associated with certain forms of leukemia transform blood cells into abnormal cancer cells. The research, published in the February issue of Cancer Cell, examines the molecular signals involved in this transformation and suggests new therapeutic approaches for a rare lethal form of childhood leukemia.

A new study provides direct evidence that mutations associated with certain forms of leukemia transform blood cells into abnormal cancer cells. The research, published in the February issue of Cancer Cell, examines the molecular signals involved in this transformation and suggests new therapeutic approaches for a rare lethal form of childhood leukemia.

Related Articles


The protein Shp2 is required for normal growth factor and cytokine signaling. Mutations in Shp2 cause Noonan Syndrome (NS), which is associated with an increased risk of juvenile myelomonocytic leukemia (JMML), and Shp2 mutations have been associated with sporadic JMML as well as other leukemias. Dr. M. Golam Mohi, a research fellow from the Neel Laboratory at Beth Israel Deaconess Medical Center, in collaboration with research groups at Brigham and Women's Hospital and Emory University, examined the effect of Shp2 mutants on bone marrow and blood cell proliferation. Leukemia-associated Shp2 mutations caused a fatal leukemia in mice that resembled JMML. The leukemia-associated Shp2 mutants were much more likely to transform bone marrow cells than NS mutants were. The researchers also discovered that Shp2 mutants exhibited a perturbation in Ras signaling, a well-established pathway that plays a key role in governing cell survival and proliferation. Specific inhibitors of Ras/Mek and Tor pathways interfered with mutant Shp2-induced proliferation of abnormal bone marrow progenitor cells, which generate blood cells.

The results presented here establish a causal link between Shp2 mutations and leukemia, and point to leukemia-associated Shp2 mutants as attractive therapeutic targets for human cancers associated with Shp2 mutation. "Current treatments for leukemia caused by Shp2 mutations are often ineffective. Given the frequently lethal outcome of Shp2-associated cancers, clinical trials of currently available Ras/Mek and/or Tor inhibitors should be considered; at least until selective Shp2 inhibitors are developed. Our mouse model of Shp2-evoked myeloproliferative disorder may provide a useful system to test these and other therapeutic approaches," offers Dr. Mohi.

###

M. Golam Mohi, Ifor R. Williams, Charles R. Dearolf, Gordon Chan, Jeffery L. Kutok, Sarah Cohen, Kelly Morgan, Christina Boulton, Hirokazu Shigematsu, Heike Keilhack, Koichi Akashi, D. Gary Gilliland and Benjamin G. Neel: "Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations"

The researchers include M. Golam Mohi, Gordon Chan, Heike Keilhack, and Benjamin G. Neel at Beth Israel Deaconess Medical Center in Boston; Ifor R. Williams at Emory University in Atlanta; Charles R. Dearolf at Massachusetts General Hospital in Boston; Jeffery L. Kutok, Sarah Cohen, Kelly Morgan, Christina Boulton, and D. Gary Gilliland at Brigham and Women's Hospital in Boston; and Hirokazu Shigematsu and Koichi Akashi at Dana-Farber Cancer Institute in Boston. This work was supported by NIH grants and grants from the Leukemia and Lymphoma Society. D.G.G. is an investigator of the HHMI. M.G.M was supported by a Hood Postdoctoral Fellowship from the Medical Foundation.

Publishing in Cancer Cell, Volume 7, Number 2, February 2005, pages 179-191. http://www.cancercell.org/


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Cite This Page:

Cell Press. "Mouse Model Of Leukemia Yields Exciting Therapeutic Implications For Rare Childhood Cancer." ScienceDaily. ScienceDaily, 22 February 2005. <www.sciencedaily.com/releases/2005/02/050218131501.htm>.
Cell Press. (2005, February 22). Mouse Model Of Leukemia Yields Exciting Therapeutic Implications For Rare Childhood Cancer. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2005/02/050218131501.htm
Cell Press. "Mouse Model Of Leukemia Yields Exciting Therapeutic Implications For Rare Childhood Cancer." ScienceDaily. www.sciencedaily.com/releases/2005/02/050218131501.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
WHO Says Male Ebola Survivors Should Abstain From Sex

WHO Says Male Ebola Survivors Should Abstain From Sex

Newsy (Nov. 28, 2014) — WHO cites four studies that say Ebola can still be detected in semen up to 82 days after the onset of symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins