Featured Research

from universities, journals, and other organizations

Mount Sinai Researchers Identify Key To Controlling HIV

Date:
March 18, 2005
Source:
Mount Sinai Hospital / Mount Sinai School Of Medicine
Summary:
Researchers at Mount Sinai School of Medicine have found alpha-defensin-1, a protein found in immune cells, can control HIV infection by at least two mechanisms. Earlier studies have primarily looked at the role of defensins in bacterial diseases.

New York - Researchers at Mount Sinai School of Medicine have found alpha-defensin-1, a protein found in immune cells, can control HIV infection by at least two mechanisms. Earlier studies have primarily looked at the role of defensins in bacterial diseases. A study published the March 1 print edition of the Journal of Clinical Investigation (JCI) examines their role as natural antiviral substances.

Theresa Chang and colleagues at Mount Sinai School of Medicine analyzed how alpha-defensin-1 inhibits HIV infection in white blood cells (CD4+ T cells). Defensins have been shown to have anti-HIV activity. The body attempts to protect itself from HIV infection via the innate immune system.

"Understanding the mechanism by which natural host defenses work against viruses such as HIV will give us insight into understanding the host virus relationship," says Theresa Chang, PhD, first author of the study and Assistant Professor of Medicine at Mount Sinai School of Medicine. "This study suggests they may be quite important not only to HIV but to other viral infections."

The researchers show that alpha-defensin-1 fights HIV in two different ways. Without serum (the watery portion of blood that remains when blood cells are removed) where viral burden is low, alpha-defensin-1 directly inactivates HIV virus. When serum is present, alpha-defensin-1 acts on vulnerable cells to block HIV infection. The authors also show that the way alpha-defensin-1 blocks HIV infection in cells is by inhibiting a CD4+ cell-signaling molecule called PKC.

"Understanding the complex interactions by which a-defensins make a cell less susceptible to HIV may open new avenues to explore for prevention and therapy," says Mary E. Klotman, MD, senior author and Chief of Infectious Diseases at Mount Sinai Medical Center.

The findings offer insight into the function of alpha-defensin-1 on both the virus and the cell and the innate immunity against HIV. In addition, this study provides a basis to develop defensin-like drugs for prevention of HIV and for therapeutic use in patients who are already infected.


Story Source:

The above story is based on materials provided by Mount Sinai Hospital / Mount Sinai School Of Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Mount Sinai Hospital / Mount Sinai School Of Medicine. "Mount Sinai Researchers Identify Key To Controlling HIV." ScienceDaily. ScienceDaily, 18 March 2005. <www.sciencedaily.com/releases/2005/03/050309110646.htm>.
Mount Sinai Hospital / Mount Sinai School Of Medicine. (2005, March 18). Mount Sinai Researchers Identify Key To Controlling HIV. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2005/03/050309110646.htm
Mount Sinai Hospital / Mount Sinai School Of Medicine. "Mount Sinai Researchers Identify Key To Controlling HIV." ScienceDaily. www.sciencedaily.com/releases/2005/03/050309110646.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins