Featured Research

from universities, journals, and other organizations

Colorectal Cancer Can Be Inherited, Researchers Report

Date:
March 16, 2005
Source:
McGill University
Summary:
Professor Jeremy R. Jass, who holds a Canada Research Chair in Gastrointestinal Pathology at McGill University in Montreal, and colleagues in Australia and Japan have shown that in some cases colorectal cancer can be inherited.

An international team of medical scientists has made an important advance in our understanding of the second most fatal form of cancer in the industrialized world. Professor Jeremy R. Jass, who holds a Canada Research Chair in Gastrointestinal Pathology at McGill University in Montreal, and colleagues in Australia and Japan have shown that in some cases colorectal cancer can be inherited.

Related Articles


The new syndrome is characterized by distinctive clinical, pathological and molecular features:

* Early age at onset

* More common in females

* More common in right side of colon

* Little evidence of tumour immunity

* Frequent mutation of an oncogene called BRAF (also mutated in cancer of thyroid, ovary, and melanoma)

* Frequent DNA methylation (chemical change which inactivates many genes)

* Frequent but variable levels of DNA instability across different colorectal cancers occurring in members of same family

* Origin in serrated polyps (considered previously to be completely benign)

Colorectal cancer is the second most frequent cause of death due to cancer (after lung cancer) in Canada and the industrialized world. It has become clear in recent years that colorectal cancer is not a single disease but a group of diseases, each with a different cause and behaviour. The genetic basis of this new syndrome is not known but it is speculated that affected families have a genetic predisposition to develop DNA methylation. There is already evidence that subjects with colorectal cancer showing DNA methylation are more likely to have a family history of colon cancer and other types of cancer. Moreover, the colorectal cancers appear to develop in polyps that have been considered to be entirely harmless and have therefore been ignored up to now. These polyps also show mutation of the oncogene BRAF and DNA methylation. It is likely that the same polyps may sometimes become malignant in patients who are not members of high-risk families.

Although familial - or inherited - forms of cancer are uncommon, they are of major importance for three reasons, says Dr Jass:

1. Such cancers often occur in young subjects and result in loss of many years of life. An appreciation of the problem can lead to cancer prevention by a combination of prevention or detection of early cancer.

2. High-risk families provide an opportunity for investigating novel approaches of cancer prevention by the use of diet or chemical compounds. The results may be generalizable to the average-risk population.

3. An understanding of the genetic defect may provide important insight into the basic cause of the common non-inherited forms of the same type of cancer.

The findings of Dr Jass and his colleagues are reported in the March 2005 edition of Clinical Gastroenterology and Hepatology, published by the American Gastroenterological Association.


Story Source:

The above story is based on materials provided by McGill University. Note: Materials may be edited for content and length.


Cite This Page:

McGill University. "Colorectal Cancer Can Be Inherited, Researchers Report." ScienceDaily. ScienceDaily, 16 March 2005. <www.sciencedaily.com/releases/2005/03/050309142157.htm>.
McGill University. (2005, March 16). Colorectal Cancer Can Be Inherited, Researchers Report. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2005/03/050309142157.htm
McGill University. "Colorectal Cancer Can Be Inherited, Researchers Report." ScienceDaily. www.sciencedaily.com/releases/2005/03/050309142157.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins