Featured Research

from universities, journals, and other organizations

Protein Delivers Selenium For Normal Sperm Development

Date:
March 17, 2005
Source:
Society For The Study Of Reproduction
Summary:
A paper to be published in the journal Biology of Reproduction offers evidence that a protein circulating in the blood of mammals delivers the dietary micronutrient selenium to germ cells, enabling these cells to develop into normal sperm.

A paper to be published in the journal Biology of Reproduction offers evidence that a protein circulating in the blood of mammals delivers the dietary micronutrient selenium to germ cells, enabling these cells to develop into normal sperm.

Previously, the function of this protein, selenoprotein P, was unknown, although it was believed to play a role as an antioxidant and to transport selenium throughout the body.

Dietary selenium is essential for normal sperm development and male fertility. Selenoprotein P, or SEPP1, carries about 60 percent of the selenium in blood plasma.

To understand the physiological function of SEPP1 in the testes and epididymis of mammals, a team of scientists at Vanderbilt University in Nashville studied male mice that lack the gene to produce SEPP1. These genetically altered males have levels of selenium in the testis that are less than 10 percent of those in control mice, and they are generally infertile.

The research team, headed by Dr. Gary E. Olson, found that the mutant male mice lacking SEPP1 develop sperm with defective tails, similar to the sperm produced by unaltered male mice fed a low-selenium diet.

Furthermore, the mutant mice do not recover normal sperm production after prolonged feeding on a diet supplemented with high levels of selenium, and they remain infertile. Thus, even selenium supplements could not overcome the need for SEPP1 to facilitate normal sperm development.

These findings, according to Olson and colleagues, strongly indicate that SEPP1 is the source of the selenium needed for development of normal sperm and for male mice to maintain their fertility.

###

Biology of Reproduction, published by the Society for the Study of Reproduction, is the top-rated peer-reviewed journal in the field of reproductive biology.


Story Source:

The above story is based on materials provided by Society For The Study Of Reproduction. Note: Materials may be edited for content and length.


Cite This Page:

Society For The Study Of Reproduction. "Protein Delivers Selenium For Normal Sperm Development." ScienceDaily. ScienceDaily, 17 March 2005. <www.sciencedaily.com/releases/2005/03/050310172851.htm>.
Society For The Study Of Reproduction. (2005, March 17). Protein Delivers Selenium For Normal Sperm Development. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2005/03/050310172851.htm
Society For The Study Of Reproduction. "Protein Delivers Selenium For Normal Sperm Development." ScienceDaily. www.sciencedaily.com/releases/2005/03/050310172851.htm (accessed April 19, 2014).

Share This



More Health & Medicine News

Saturday, April 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins