Featured Research

from universities, journals, and other organizations

Diagnostic Test For Range Of Blood Disorders On The Horizon

Date:
April 4, 2005
Source:
Lancet
Summary:
Scientists have discovered a single mutation that is responsible for a number of blood disorders, reporting their findings in this week's issue of THE LANCET.

Scientists have discovered a single mutation that is responsible for a number of blood disorders, reporting their findings in this week's issue of THE LANCET.

Myeloproliferative disorders form a range of haematological malignant diseases, with three main members: polycythaemia vera, essential thrombocythaemia, and idiopathic myelofibrosis. The disorders are characterised by overactive production of blood cells and can lead to thrombosis, haemorrhage or acute myeloid leukaemia. The absence of a definitive diagnostic test and the scarcity of randomised clinical trials make management of these diseases especially challenging.

Tony Green (Cambridge Institute for Medical Research, UK) and colleagues analysed a candidate gene called JAK2 in 140 patients with myeloproliferative disorders from haematological clinics in the UK. They also took control DNA samples from a population of patients with type 1 diabetes. A single point mutation was identified in the JAK2 gene in 71 (97%) of 73 patients with polycythaemia vera, 29 (57%) of 51 with essential thrombocythaemia, and eight (50%) of 16 with idiopathic myelofibrosis. The mutation was not detected in any of the controls.

Distinguishing myeloproliferative disorders from other blood disorders such as thrombocytosis can be difficult; the authors suggest the detection of the JAK2 mutation could become a widely used diagnostic test.

Professor Green concludes: "For more than a quarter of a century, the myeloproliferative disorders have been known to be clonal haematological malignancies, but the identity of underlying target genes has remained elusive. We have shown that a single acquired point mutation in JAK2 is present in virtually all patients with polycythaemia vera and in about half of those with either essential thrombocythaemia or idiopathic myelofibrosis. It is also important to acknowledge the work of several other research groups who have similar data submitted for publication. These exciting results have important implications for the classification, diagnosis, and treatment of the myeloproliferative disorders and provide insight into their pathogenesis."


Story Source:

The above story is based on materials provided by Lancet. Note: Materials may be edited for content and length.


Cite This Page:

Lancet. "Diagnostic Test For Range Of Blood Disorders On The Horizon." ScienceDaily. ScienceDaily, 4 April 2005. <www.sciencedaily.com/releases/2005/03/050325232546.htm>.
Lancet. (2005, April 4). Diagnostic Test For Range Of Blood Disorders On The Horizon. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2005/03/050325232546.htm
Lancet. "Diagnostic Test For Range Of Blood Disorders On The Horizon." ScienceDaily. www.sciencedaily.com/releases/2005/03/050325232546.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins