Featured Research

from universities, journals, and other organizations

A Regulatory Network Analysis Of Phenotypic Plasticity In Yeast

Date:
April 11, 2005
Source:
University Of Chicago Press Journals
Summary:
Molecular biologists have found that the connectedness of genes and proteins is correlated with a range of phenomena, from how essential genes are, to the rates at which they have evolved, to the probability that they are lost over evolutionary time. In the yeast gene regulatory network, some genes are turned on and off by just one 'regulatory gene' while others are influenced by ten or more regulatory genes.

Networks are everywhere. Trying to catch connecting flights as we shuttle from one airport to the next can make distances between cities seem even greater than they are. Discovering that you are sitting next to a friend of a friend on one of those flights (social contact networks) can make the world seem a much smaller place. Diverse networks, from airports to social interactions to genes and proteins, often have surprisingly similar structure. In all of these networks, some nodes are highly connected to many other nodes, while most tend to have just a few connections. Molecular biologists have found that the connectedness of genes and proteins is correlated with a range of phenomena, from how essential genes are, to the rates at which they have evolved, to the probability that they are lost over evolutionary time. In the yeast gene regulatory network, some genes are turned on and off by just one 'regulatory gene' while others are influenced by ten or more regulatory genes. In a study of this network, to be published in the May 2005 issue of American Naturalist, Daniel E. L. Promislow (University of Georgia) now shows that network structure can be used to understand ecological relevant traits.

Promislow analyzes the yeast gene regulatory to understand how genes influence phenotypic plasticity. 'Phenotypic plasticity' refers to the ability of genetically identical organisms to alter their phenotype in response to an environmental change. For example, genetically identical plants grown in sun versus shade will soon look very different from one another.

It turns out that some species are more plastic than others. Until now, we have not been able to determine what kinds of genes determine whether or not an organism displays phenotypic plasticity. A previous study measured variation in activity level for each of the roughly 6000 genes found in yeast across a range of stressful environments. Some genes varied enormously in their expression levels from one environment to the next, while others were relatively constant. That is, some genes were more plastic than others. Promislow has now discovered that the more regulators a gene has, the more plastic the gene. Furthermore, he shows that the plasticity of a gene depends on its function. From these simple patterns, we gain insight into the complex genetic architecture that determines how well an organism can respond to environmental change.


Story Source:

The above story is based on materials provided by University Of Chicago Press Journals. Note: Materials may be edited for content and length.


Cite This Page:

University Of Chicago Press Journals. "A Regulatory Network Analysis Of Phenotypic Plasticity In Yeast." ScienceDaily. ScienceDaily, 11 April 2005. <www.sciencedaily.com/releases/2005/03/050326000025.htm>.
University Of Chicago Press Journals. (2005, April 11). A Regulatory Network Analysis Of Phenotypic Plasticity In Yeast. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2005/03/050326000025.htm
University Of Chicago Press Journals. "A Regulatory Network Analysis Of Phenotypic Plasticity In Yeast." ScienceDaily. www.sciencedaily.com/releases/2005/03/050326000025.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins