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DNA Vaccine Protects Against AIDS, Not HIV

Date:
April 20, 2005
Source:
American Society For Microbiology
Summary:
While a new DNA vaccine may not be able to prevent HIV infection, it could protect against progression to full-blown AIDS. Researchers from Kansas report their findings in the March 2005 issue of the Journal of Virology.
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While a new DNA vaccine may not be able to prevent HIV infection, it could protect against progression to full-blown AIDS. Researchers from Kansas report their findings in the March 2005 issue of the Journal of Virology.

Developing a vaccine to protect against HIV in attempt to gain control of the AIDS pandemic is a top priority for researchers throughout the world. Extensive testing has been conducted with live vaccines to determine if immunization would be effective at prevention, but they are not suitable for human use due to the potential that the vaccine viruses could mutate and reacquire the ability to cause disease.

DNA vaccines offer a new possibility for treatment. The have the advantages of safety, low cost of production, and ease of use in field conditions due to their minimal need for refrigeration.

In the study the DNA of a simian/human immunodeficiency virus (SHIV) was made noninfectious by removing the gene that makes reverse transciptase (a protein the virus requires to replicate). Four macaques were injected with the noninfectious vaccine, while two control animals remained unvaccinated. Both groups were challenged with SHIV. All four of the immunized macaques became infected with the challenge virus, but three survived. The two control subjects died.

“The results showed strong evidence that this type of vaccine could prevent AIDS and established that a DNA vaccine, such as this one, could be used alone, without the need for booster doses with viral proteins, for large-scale immunization programs,” say the researchers.

(D.K. Singh, Z. Liu, D. Sheffer, G.A. Mackay, M. Smith, S. Dhillon, R. Hegde, F. Jia, I. Adany, O. Narayan. 2005. A noninfectious simian/human immunodeficiency virus DNA vaccine that protects macaques against AIDS. Journal of Virology, 79. 6: 3419-3428.)


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The above post is reprinted from materials provided by American Society For Microbiology. Note: Materials may be edited for content and length.


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American Society For Microbiology. "DNA Vaccine Protects Against AIDS, Not HIV." ScienceDaily. ScienceDaily, 20 April 2005. <www.sciencedaily.com/releases/2005/04/050419105400.htm>.
American Society For Microbiology. (2005, April 20). DNA Vaccine Protects Against AIDS, Not HIV. ScienceDaily. Retrieved August 5, 2015 from www.sciencedaily.com/releases/2005/04/050419105400.htm
American Society For Microbiology. "DNA Vaccine Protects Against AIDS, Not HIV." ScienceDaily. www.sciencedaily.com/releases/2005/04/050419105400.htm (accessed August 5, 2015).

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