Featured Research

from universities, journals, and other organizations

Propensity For Obesity, Diabetes, May Occur In Utero

Date:
April 22, 2005
Source:
University at Buffalo
Summary:
The adage "You are what you eat" should be rephrased to include "and so are your children," based on metabolic research pioneered by researchers at the University at Buffalo.

BUFFALO, N.Y. -- The adage "You are what you eat" should be rephrased to include "and so are your children," based on metabolic research pioneered by researchers at the University at Buffalo.

Previous studies by the UB scientists showed that rat pups raised artificially on a high-carbohydrate milk formula identical in calories to mother's milk developed changes in pancreatic islets, resulting in overproduction of insulin and obesity in adulthood.

The progeny of these high-carbohydrate (HC) mothers raised naturally also develop the same maladjustments, they found.

The researchers now have shown that this metabolic "malprogramming" is permanent and occurs in utero, resulting in the next generation born to HC mothers carrying the HC phenotype. Rat fetuses had increased plasma insulin levels, increased mRNA levels of preproinsulin, a precursor of insulin, and increased insulin in the pancreas, without an increase in body weight, plasma glucose level or a change in islet structure.

They also found changes in the hypothalamus, the brain's center of appetite regulation, that result in appetite stimulation.

While these studies were done with rats, Mulchand Patel, Ph.D, UB distinguished professor of biochemistry and first author on the study, speculated that there is good reason to think the mechanism could be similar in humans.

"Obesity can be perpetuated via the maternal intrauterine environment," said Patel, who reported the findings at the 2005 Experimental Biology meeting held in San Diego in early April.

"Our earlier studies looked at progeny in the post-weaning period, so we didn't know how early this malprogramming occurred. Now we know it occurs in utero. We predicted that this could be the case, and our present findings support this prediction."

Plasma levels of rat pups (2-HC) born to HC mothers returned to normal during the suckling period, results showed, but islets from 12-day-old suckling 2-HC rats showed a capacity for insulin oversecretion when maintained in culture medium containing high glucose levels. By the 28th day, approximately 4 days after weaning to rat chow, 2-HC rats once again had high insulin levels and showed a higher capacity for insulin secretion to a glucose stimulus. Even on rat chow, body weight began to increase around day 55, and 2-HC rats were obese by post-natal day 100.

Patel speculated that in humans, it's possible such malprogramming could be interrupted if an obese/insulin resistant mother brought body weight and plasma insulin levels back to normal before becoming pregnant.

Malathi Srinivasan. Ph.D, Suhad Shbeir-ElDika, Ravikumar Aalinkeel, Ph.D., Fei Song, Ph.D., Lioudmila Pliss, Ph.D., and Paul Mitrani from Patel's lab, along with Roberta Pentney, Ph.D., from the UB Department of Pathology and Anatomical Sciences, also contributed to the study, as well as Shanthie Damodaran, Ph.D., and Sherin Devaskar M.D., from the Department of Pediatrics at UCLA, and Brenda Strutt and David Hill Ph.D., from the Lawson Research Institute in London, Ontario.

The research was supported by grants from the National Institutes of Health.


Story Source:

The above story is based on materials provided by University at Buffalo. Note: Materials may be edited for content and length.


Cite This Page:

University at Buffalo. "Propensity For Obesity, Diabetes, May Occur In Utero." ScienceDaily. ScienceDaily, 22 April 2005. <www.sciencedaily.com/releases/2005/04/050421212603.htm>.
University at Buffalo. (2005, April 22). Propensity For Obesity, Diabetes, May Occur In Utero. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2005/04/050421212603.htm
University at Buffalo. "Propensity For Obesity, Diabetes, May Occur In Utero." ScienceDaily. www.sciencedaily.com/releases/2005/04/050421212603.htm (accessed April 24, 2014).

Share This



More Health & Medicine News

Thursday, April 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
Hagel Gets Preview of New High-Tech Projects

Hagel Gets Preview of New High-Tech Projects

AP (Apr. 22, 2014) Defense Secretary Chuck Hagel is given hands-on demonstrations Tuesday of some of the newest research from DARPA _ the military's Defense Advanced Research Projects Agency program. (April 22) Video provided by AP
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins