Featured Research

from universities, journals, and other organizations

Propensity For Obesity, Diabetes, May Occur In Utero

Date:
April 22, 2005
Source:
University at Buffalo
Summary:
The adage "You are what you eat" should be rephrased to include "and so are your children," based on metabolic research pioneered by researchers at the University at Buffalo.

BUFFALO, N.Y. -- The adage "You are what you eat" should be rephrased to include "and so are your children," based on metabolic research pioneered by researchers at the University at Buffalo.

Related Articles


Previous studies by the UB scientists showed that rat pups raised artificially on a high-carbohydrate milk formula identical in calories to mother's milk developed changes in pancreatic islets, resulting in overproduction of insulin and obesity in adulthood.

The progeny of these high-carbohydrate (HC) mothers raised naturally also develop the same maladjustments, they found.

The researchers now have shown that this metabolic "malprogramming" is permanent and occurs in utero, resulting in the next generation born to HC mothers carrying the HC phenotype. Rat fetuses had increased plasma insulin levels, increased mRNA levels of preproinsulin, a precursor of insulin, and increased insulin in the pancreas, without an increase in body weight, plasma glucose level or a change in islet structure.

They also found changes in the hypothalamus, the brain's center of appetite regulation, that result in appetite stimulation.

While these studies were done with rats, Mulchand Patel, Ph.D, UB distinguished professor of biochemistry and first author on the study, speculated that there is good reason to think the mechanism could be similar in humans.

"Obesity can be perpetuated via the maternal intrauterine environment," said Patel, who reported the findings at the 2005 Experimental Biology meeting held in San Diego in early April.

"Our earlier studies looked at progeny in the post-weaning period, so we didn't know how early this malprogramming occurred. Now we know it occurs in utero. We predicted that this could be the case, and our present findings support this prediction."

Plasma levels of rat pups (2-HC) born to HC mothers returned to normal during the suckling period, results showed, but islets from 12-day-old suckling 2-HC rats showed a capacity for insulin oversecretion when maintained in culture medium containing high glucose levels. By the 28th day, approximately 4 days after weaning to rat chow, 2-HC rats once again had high insulin levels and showed a higher capacity for insulin secretion to a glucose stimulus. Even on rat chow, body weight began to increase around day 55, and 2-HC rats were obese by post-natal day 100.

Patel speculated that in humans, it's possible such malprogramming could be interrupted if an obese/insulin resistant mother brought body weight and plasma insulin levels back to normal before becoming pregnant.

Malathi Srinivasan. Ph.D, Suhad Shbeir-ElDika, Ravikumar Aalinkeel, Ph.D., Fei Song, Ph.D., Lioudmila Pliss, Ph.D., and Paul Mitrani from Patel's lab, along with Roberta Pentney, Ph.D., from the UB Department of Pathology and Anatomical Sciences, also contributed to the study, as well as Shanthie Damodaran, Ph.D., and Sherin Devaskar M.D., from the Department of Pediatrics at UCLA, and Brenda Strutt and David Hill Ph.D., from the Lawson Research Institute in London, Ontario.

The research was supported by grants from the National Institutes of Health.


Story Source:

The above story is based on materials provided by University at Buffalo. Note: Materials may be edited for content and length.


Cite This Page:

University at Buffalo. "Propensity For Obesity, Diabetes, May Occur In Utero." ScienceDaily. ScienceDaily, 22 April 2005. <www.sciencedaily.com/releases/2005/04/050421212603.htm>.
University at Buffalo. (2005, April 22). Propensity For Obesity, Diabetes, May Occur In Utero. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2005/04/050421212603.htm
University at Buffalo. "Propensity For Obesity, Diabetes, May Occur In Utero." ScienceDaily. www.sciencedaily.com/releases/2005/04/050421212603.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins