Featured Research

from universities, journals, and other organizations

Lipoprotein Abnormalities Found In Severely Obese Children

Date:
May 1, 2005
Source:
American Heart Association
Summary:
Severely obese children have lipoprotein profiles that signal early risk of cardiovascular disease and the metabolic syndrome.

WASHINGTON, D.C., April 30 -- Severely obese children have lipoprotein profiles that signal early risk of cardiovascular disease and the metabolic syndrome, according to a study presented at the American Heart Association's Sixth Annual Scientific Conference on Arteriosclerosis, Thrombosis and Vascular Biology.

"The message is urgent about the importance of prevention of cardiovascular disease in childhood. Lifestyle modification with appropriate diet and exercise can reduce cardiovascular risk in children," said lead author Daniel L. Preud'Homme, M.D., associate professor of medicine at the Wright State University School of Medicine and director of the lipid clinic at The Children's Medical Center, both in Dayton, Ohio.

Lipoproteins transport cholesterol throughout the body. Lipoprotein subclasses and the size of lipoprotein particles can be measured by a test that uses nuclear magnetic resonance (NMR) spectroscopy to provide a more detailed lipid profile than standard lipid panels.

High-density lipoprotein (HDL) is sometimes called "good" cholesterol because it returns cholesterol to the liver where it can be eliminated. Low-density lipoprotein (LDL) is often called "bad" cholesterol because of its association with clogged arteries and increased cardiovascular risk. In addition, studies have linked smaller LDL particle size with higher risk.

The study focused on 160 children, average age 12.6 years, who were evaluated at Wright State University's pediatric lipid clinic. Severe (morbid) obesity was defined as body mass index (BMI) of 36 and above, which is higher than that of 99 percent of children the same age and gender (the 99th percentile on BMI growth charts).

Of the children, 53 percent were boys and 47 percent were girls. Seventy percent were categorized as white/other, including four children who were Hispanic, Native American or Asian, while 30 percent were black.

They found differences between black and white children in the sizes and subclasses of the lipoproteins.

"The obese white children have significantly higher early risk of cardiovascular disease than the obese black children according to this test," Preud'Homme said.

This was an unexpected finding because other studies have found the opposite to be true in the general population for a variety of risk factors including high blood pressure and type 2 diabetes, he said.

In this study, differences between the two groups include:

  • Low levels of "good" large HDL particles were found in 46 percent of white children compared to 29 percent of black children, representing significantly increased cardiovascular risk.
  • High levels of large very low-density lipoprotein (VLDL) were identified in 62 percent of white children compared to 31 percent of black children, also a significant increase in risk.
  • LDL pattern B -- a lipid profile with an unusually high number of small, dense LDL particles that is thought to confer higher cardiovascular risk -- was found in 45 percent of white children compared to 19 percent of black children.
  • Obese white children were shown to have a higher risk of experiencing the dyslipidemia associated with metabolic syndrome than obese black children. Fifty-three percent of white children were identified with two or more blood lipoprotein levels associated with metabolic syndrome (small LDL, low numbers of large HDL and increased VLDL) compared to 21 percent of black children.

Lipid abnormalities are part of a cluster of conditions comprising the metabolic syndrome. Metabolic syndrome is also closely associated with a generalized metabolic disorder called insulin resistance, in which the body cannot efficiently use insulin. People with the metabolic syndrome are at increased risk of coronary heart disease, stroke, peripheral vascular disease and type 2 diabetes.

The study found no gender differences for lipoprotein variables.

His co-author is Adrienne Stolfi, M.S.



Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "Lipoprotein Abnormalities Found In Severely Obese Children." ScienceDaily. ScienceDaily, 1 May 2005. <www.sciencedaily.com/releases/2005/04/050430221745.htm>.
American Heart Association. (2005, May 1). Lipoprotein Abnormalities Found In Severely Obese Children. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2005/04/050430221745.htm
American Heart Association. "Lipoprotein Abnormalities Found In Severely Obese Children." ScienceDaily. www.sciencedaily.com/releases/2005/04/050430221745.htm (accessed September 1, 2014).

Share This




More Health & Medicine News

Monday, September 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

Reuters - US Online Video (Aug. 30, 2014) California lawmakers pass a bill requiring universities to adopt "affirmative consent" language in their definitions of consensual sex, part of a nationwide drive to curb sexual assault on campuses. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
New Drug Could Reduce Cardiovascular Deaths

New Drug Could Reduce Cardiovascular Deaths

Newsy (Aug. 30, 2014) The new drug from Novartis could reduce cardiovascular deaths by 20 percent compared to other similar drugs. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins