Featured Research

from universities, journals, and other organizations

Scientists Develop Technology To Detect Cancer

Date:
June 2, 2005
Source:
University of Liverpool
Summary:
Researchers at the University of Liverpool have developed a breakthrough technology that identifies molecular markers in early lung cancer.

Researchers at the University of Liverpool have developed a breakthrough technology that identifies molecular markers in early lung cancer.

The new technology, created in collaboration with SEQUENOM, developers of genetic analysis products, and Methexis Genomics, uses a DNA analysis technique called methylation profiling to detect cells in the lung that are likely to become cancerous.

There are a number of genetic mechanisms that can alter the characteristics of a normal cell and change it into a cancer cell. One of these mechanisms is methylation, which causes a change in the DNA structure of particular genes and results in altering its control -- this may switch the gene on or off at the wrong time in the cell cycle.

Dr Lakis Liloglou, Head of the University's Lung Cancer Molecular Biomarkers Group, explains: "This is of particular importance in lung cancer research, as the changes in methylation status of the DNA are considered to be a marker for early disease detection.

"Even though DNA methylation analysis has been a previous area of research, prior techniques had a range of technical limitations, that prevented them from being of any real clinical use. This newly developed method overcomes many of the problems and combines the sensitivity of high-powered microscopes with the capability of analysing many samples at a time."

As part of their research to develop the new technology, the team, based at the University of Liverpool Cancer Research Centre, analysed the methylation profile of 47 genes in lung specimens from 48 patients with a history of smoking. The genes that were selected were known to be involved in cancer development and in this study they were able to accurately determine the relationship between gene methylation in normal and tumour tissue, which in the long term will be of enormous value in identifying high risk individuals.

Professor John Field, Director of the Roy Castle Lung Cancer Research Programme, said: "Early detection of lung cancer is the prime objective of our research programme. This depends on the identification of early biomarkers in patients who are at risk of developing the disease prior to clinical symptoms."

"The partnership between the University and Sequenom has provided a breakthrough in our goal to detect early genetic changes in individuals who are at the highest risk."

###

The research is being presented this week at the 96th annual meeting of the American Association for Cancer Research (AACR) in Anaheim, California.


Story Source:

The above story is based on materials provided by University of Liverpool. Note: Materials may be edited for content and length.


Cite This Page:

University of Liverpool. "Scientists Develop Technology To Detect Cancer." ScienceDaily. ScienceDaily, 2 June 2005. <www.sciencedaily.com/releases/2005/06/050602012826.htm>.
University of Liverpool. (2005, June 2). Scientists Develop Technology To Detect Cancer. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2005/06/050602012826.htm
University of Liverpool. "Scientists Develop Technology To Detect Cancer." ScienceDaily. www.sciencedaily.com/releases/2005/06/050602012826.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com
Tooth Plaque Provides Insight Into Diets Of Ancient People

Tooth Plaque Provides Insight Into Diets Of Ancient People

Newsy (July 19, 2014) Research on plaque from ancient teeth shows that our prehistoric ancestor's had a detailed understanding of plants long before developing agriculture. Video provided by Newsy
Powered by NewsLook.com
Contaminated Water Kills 3 Babies in South African Town

Contaminated Water Kills 3 Babies in South African Town

AFP (July 18, 2014) Contaminated water in South Africa's northwestern town of Bloemhof kills three babies and hospitalises over 500 people. The incident highlights growing fears over water safety in South Africa. Duration: 02:22 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins